Blood-catalyzed n-doped polymers for reversible optical neural control

• 成果类型: Article
• 署名作者: Samal, Sanket; Xiao, Shulan; Nelson, Samantha; Kolhe, Om; Khan, Hammad F.; Matin, Meisam Habibi; Lee, Won-June; Ahmed, Mustafa; Wang, Decheng; Wang, Tianqi; Pikes, Tyler; Scott, Alicia N.; Rodriguez, J. Alejandra; Olson, Matthew R.; Deng, Qing; Parkinson, Elizabeth I.; Rochet, Jean-Christophe; Jayant, Krishna; Mei, Jianguo
• 署名单位: Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adu5500
• 发表日期: 2026-04-02
• 页码: eadu5500
• 关键词: MEDIATED SYNTHESIS; conductivity; inhibition; tissues; iron

摘要

Biocompatible integration of synthetic materials with living tissue remains a major challenge for bioelectronics. In this case, substrate-free conducting polymer (CP) interfaces could help bridge this gap. We report in vivo assembly of n-doped poly(benzodifurandione) (n-PBDF) using whole blood-catalyzed polymerization in awake zebrafish and mice. This approach leverages endogenous catalysts, specifically hemoproteins, to form stable, thermally and ionically sensitive CP networks, ensuring long-term compatibility throughout the lifespan. We showcase the impact of this interface through reversible, cellular, and subcellular neuromodulation using near-infrared (NIR) light, including in vivo polymerized n-PBDF. Electrophysiological studies confirmed that n-PBDF alters intrinsic sodium ion channel excitability, and NIR light stimulation amplifies this modulation through thermoionic-induced shunting, providing on-demand, millisecond-scale reversible inhibitory control of excitability, a feature recapitulated in actively behaving mice.