2-STAGE SELECTION AND TESTING DESIGNS FOR COMPARATIVE CLINICAL-TRIALS
成果类型：
Article
署名作者：
THALL, PF; SIMON, R; ELLENBERG, SS
署名单位：
National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.2307/2336178
发表日期：
1988
页码：
303310
关键词：
摘要：
A two-stage design which selects the best of several experimental treatments and compares it to a standard control is proposed. The design allows early termination with acceptance of the global null hypothesis. Optimal sample size and cut-off parameters are obtained by minimizing expected total sample size for fixed significance level and power.
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