Individuals with substance use disorders experience an increased urge to move to complex music

• 成果类型: Article
• 署名作者: Stupacher, Jan; Matarrelli, Benedetta; Cozzoli, Danilo; Ventura, Mario; Montinaro, Francesco; de Gennaro, Luciana; Vuust, Peter; Brattico, Elvira
• 署名单位: Aarhus University; Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; University of Tartu
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15272
• DOI: 10.1073/pnas.2502656122
• 发表日期: 2025-05-20
• 关键词: sensation seeking; addiction; pleasure

摘要

Substance use disorders disrupt the dopaminergic system of the human brain, which plays a central role in movement and reward processing, altering perception, and cognition. The pleasurable urge to move to music, known as groove, relies on dopamine for reward, anticipation, beat perception, and motor system activity. Using a well- established paradigm, which shows an inverted- U relationship between groove and musical complexity, we investigated how dopamine downregulation from long- term cocaine and heroin use affects the experience of music. Drug users experienced stronger groove with high rhythmic and harmonic complexities than nonusers, while moderate complexities elicited similar responses across groups. This pattern differs from other populations with altered dopaminergic function, such as Parkinson's disease or musical anhedonia, highlighting a distinct effect of drug addiction on music perception. The findings suggest that drug users seek more intense and complex stimulation, supporting the hypothesis that a hypodopaminergic state associated with drug use raises the threshold for nondrug stimuli to engage the reward system.