Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement

• 成果类型: Article
• 署名作者: Jiang, Qiufen; Wu, Sherry Jingjing; Fishell, Gord; Chen, Chinfei
• 署名单位: Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-12896
• DOI: 10.1073/pnas.2504224122
• 发表日期: 2025-06-24
• 关键词: primary visual-cortex; metabotropic glutamate receptors; critical-period plasticity; dependent plasticity; neurons; experience; transmission; maturation; feedback; thalamus

摘要

Refinement of thalamic circuits is crucial for the proper maturation of sensory circuits. In the visual system, this process is regulated by corticothalamic feedback during the experience- dependent phase of development. Yet the cortical circuits modulating this feedback remain elusive. Here, we demonstrate opposing roles for cortical somatostatin during the thalamic sensitive period (P20- 30). Early in the refinement process, SST interneurons promote the strengthening and pruning of retinal inputs in the thalamus, as evidenced by disrupted synaptic refinement following their ablation. In contrast, PV interneurons, which mature later, act as a brake on this refinement, with their ablation leading to enhanced pruning of retinogeniculate connections. Notably, manipulating the relative balance between these inhibitory circuits can regulate sensory antagonism that gates cortical feedback regulation of feedforward thalamic refinement.