Retinal ganglion cells encode the direction of motion outside their classical receptive field

• 成果类型: Article
• 署名作者: Riccitelli, Serena; Yaakov, Hadar; Heukamp, Alina S.; Ankri, Lea; Etzion, Michal Rivlin -
• 署名单位: Weizmann Institute of Science
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11087
• DOI: 10.1073/pnas.2415223122
• 发表日期: 2025-01-07
• 关键词: amacrine cells; surround suppression; functional circuitry; spatial-distribution; contrast gain; inhibition; responses; transmission; signals; object

摘要

Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large- scale recordings in the mouse retina, we show that motion direction, in response to a stimulus crossing an area far beyond the classic receptive field. The extraclassical response arises via inputs from an asymmetric distal zone and is enhanced by desensitization mechanisms and an inherent DS component, creating a network of neurons responding to motion toward the optic disc. Pharmacological manipulations revealed the necessity of glycinergic amacrine cells for this response. Using in vivo recordings, we identified similar extraclassical responses in lateral geniculate nucleus neurons, suggesting such non conventional DS information is transferred to downstream structures. Our results suggest a complex integration of motion direction processing across the visual field, which arises beyond the classical receptive field boundaries.