A distributed subcortical circuit linked to instrumental information- seeking about threat

• 成果类型: Article
• 署名作者: Trier, Hailey A.; Khalighinejad, Nima; Hamilton, Sorcha; Harbison, Caroline; Priestley, Luke; Laubach, Mark; Klein-Fluegge, Miriam; Scholl, Jacqueline; Rushworth, Matthew F. S.
• 署名单位: University of Oxford; American University; University of Oxford; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); University of Oxford
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10608
• DOI: 10.1073/pnas.2410955121
• 发表日期: 2025-01-21
• 关键词: prefrontal cortex; habenula; robust; optimization; REGISTRATION; projections; serotonin; decisions; accurate; monkey

摘要

Daily life for humans and other animals requires switching between periods of threatand reward- oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, between foraging for rewards and seeking information about potential threats with 7T fMRI in healthy humans. Switching was driven by estimates of likelihood of threat and reward. Both tracking of threat and switching to a vigilant mode in which people sought more information about potential threats were associated with specific but distributed patterns of activity spanning habenula, dorsal raphe nucleus (DRN), anterior cingulate cortex, and anterior insula cortex. Different aspects of the distributed activity patterns were linked to monitoring the threat level, seeking information about the threat, and actual threat detection. A distinct pattern of activity in the same circuit and elsewhere occurred during returns to reward- oriented behavior. Individual variation in DRN activity reflected individual variation in the seeking of information about threats.