Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode

• 成果类型: Article
• 署名作者: Chen, Sihan; Huang, Siyuan; Son, Jangyup; Han, Edmund; Watanabe, Kenji; Taniguchi, Takashi; Huang, Pinshane Y.; King, William P.; Zande, Arend M. van der; Bashir, Rashid
• 署名单位: University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; National Institute for Materials Science; National Institute for Materials Science; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Chan Zuckerberg Initiative (CZI); University of Illinois System; University of Illinois Urbana-Champaign; Korea Institute of Science & Technology (KIST); Jeonbuk National University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10570
• DOI: 10.1073/pnas.2422135122
• 发表日期: 2025-05-06
• 关键词: graphene nanoribbon; current signals; trans location; performance; dependence; sensors; layer; gate

摘要

A long-unrealized goal in solid-state nanopore sensing is to achieve out-of-plane electrical sensing and control of DNA during translocation, which is a prerequisite for base-by-base ratcheting that enables DNA sequencing in biological nanopores. Two-dimensional (2D) heterostructures, with their capability to construct out-of-plane electronics with atomic layer precision, are ideal yet unexplored candidates for use as electrical sensing membranes. Here, we demonstrate a nanopore architecture using a vertical 2D heterojunction diode consisting of p-type WSe2 on n-type MoS2. This diode exhibits rectified interlayer tunneling currents modulated by ionic potential, while the heterojunction potential reciprocally rectifies ionic transport through the nanopore. We achieve concurrent detection of DNA translocation using both ionic and diode currents and demonstrate a 2.3-fold electrostatic slowing of average translocation speed. Encapsulation layers enhance chemical and mechanical stability and durability while preserving the spatial resolution of atomically sharp 2D heterointerface for sensing. These results establish a paradigm for out-of-plane electrical sensing of single biomolecules.