The Annals of Applied Statistics

最新文章

• STATIC AND ROVING SENSOR DATA FUSION FOR SPATIO-TEMPORAL HAZARD MAPPING WITH APPLICATION TO OCCUPATIONAL EXPOSURE ASSESSMENT AI翻译
  作者：Ludwig, Guilherme; Chu, Tingjin; Zhu, Jun; Wang, Haonan; Koehler, Kirsten
  作者单位：University of Wisconsin System; University of Wisconsin Madison; Renmin University of China; University of Wisconsin System; University of Wisconsin Madison; Colorado State University System; Colorado State University Fort Collins; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
  摘要：Rapid technological advances have drastically improved the data collection capacity in occupational exposure assessment. However, advanced statistical methods for analyzing such data and drawing proper inference remain limited. The objectives of this paper are (1) to provide new spatio-temporal methodology that combines data from both roving and static sensors for data processing and hazard mapping across space and over time in an indoor environment, and (2) to compare the new method with the ...
• INTEGRATIVE SPARSE K-MEANS WITH OVERLAPPING GROUP LASSO IN GENOMIC APPLICATIONS FOR DISEASE SUBTYPE DISCOVERY AI翻译
  作者：Huo, Zhiguang; Tseng, George
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Cancer subtypes discovery is the first step to deliver personalized medicine to cancer patients. With the accumulation of massive multi-level omics datasets and established biological knowledge databases, omics data integration with incorporation of rich existing biological knowledge is essential for deciphering a biological mechanism behind the complex diseases. In this manuscript, we propose an integrative sparse K-means (IS-Kmeans) approach to discover disease subtypes with the guidance of ...
• EVALUATION OF THE COOLING TREND IN THE IONOSPHERE USING FUNCTIONAL REGRESSION WITH INCOMPLETE CURVES AI翻译
  作者：Gromenko, Oleksandr; Kokoszka, Piotr; Sojka, Jan
  作者单位：Colorado State University System; Colorado State University Fort Collins; Utah System of Higher Education; Utah State University; Utah System of Higher Education; Utah State University
  摘要：We develop a statistical framework to test the hypothesis of the existence of an ionospheric cooling trend related to the global warming hypothesis; both are attributed to the same driver, namely the increased concentration of greenhouse gases. However, the study of a temporal trend in the ionosphere is easier because there are fewer covariates to be taken into account. The hypothesis that a cooling trend in the ionosphere exists has been an important focus of space physics research for over t...
• ASSIGNMENT OF ENDOGENOUS RETROVIRUS INTEGRATION SITES USING A MIXTURE MODEL AI翻译
  作者：Hunter, David R.; Bao, Le; Poss, Mary
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Structural variation occurs in the genomes of individuals because of the different positions occupied by repetitive genome elements like endogenous retroviruses, or ERVs. The presence or absence of ERVs can be determined by identifying the junction with the host genome using high-throughput sequence technology and a clustering algorithm. The resulting data give the number of sequence reads assigned to each ERV-host junction sequence for each sampled individual. Variability in the number of rea...
• LATERAL TRANSFER IN STOCHASTIC DOLLO MODELS AI翻译
  作者：Kelly, Luke J.; Nicholls, Geoff K.
  作者单位：University of Oxford
  摘要：Lateral transfer, a process whereby species exchange evolutionary traits through nonancestral relationships, is a frequent source of model misspecification in phylogenetic inference. Lateral transfer obscures the phylogenetic signal in the data as the histories of affected traits are mosaics of the overall phylogeny. We control for the effect of lateral transfer in a Stochastic Dollo model and a Bayesian setting. Our likelihood is highly intractable, as the parameters are the solution of a seq...
• MODELLING INDIVIDUAL MIGRATION PATTERNS USING A BAYESIAN NONPARAMETRIC APPROACH FOR CAPTURE-RECAPTURE DATA AI翻译
  作者：Matechou, Eleni; Caron, Francois
  作者单位：University of Kent; University of Oxford
  摘要：We present a Bayesian nonparametric approach for modelling wildlife migration patterns using capture-recapture (CR) data. Arrival times of individuals are modelled in continuous time and assumed to be drawn from a Poisson process with unknown intensity function, which is modelled via a flexible nonparametric mixture model. The proposed CR framework allows us to estimate the following: (i) the total number of individuals that arrived at the site, (ii) their times of arrival and departure, and h...
• FORECASTING SEASONAL INFLUENZA WITH A STATE-SPACE SIR MODEL AI翻译
  作者：Osthus, Dave; Hickmann, Kyle S.; Caragea, Petruta C.; Higdon, Dave; Del Valle, Sara Y.
  作者单位：United States Department of Energy (DOE); Los Alamos National Laboratory; Iowa State University; Virginia Polytechnic Institute & State University
  摘要：Seasonal influenza is a serious public health and societal problem due to its consequences resulting from absenteeism, hospitalizations, and deaths. The overall burden of influenza is captured by the Centers for Disease Control and Prevention's influenza-like illness network, which provides invaluable information about the current incidence. This information is used to provide decision support regarding prevention and response efforts. Despite the relatively rich surveillance data and the recu...
• ALLELE-SPECIFIC COPY NUMBER ESTIMATION BY WHOLE EXOME SEQUENCING AI翻译
  作者：Chen, Hao; Jiang, Yuchao; Maxwell, Kara N.; Nathanson, Katherine L.; Zhang, Nancy
  作者单位：University of California System; University of California Davis; University of Pennsylvania; University of Pennsylvania
  摘要：Whole exome sequencing is currently a technology of choice in large-scale cancer genomics studies, where the priority is to identify cancer-associated variants in coding regions. We describe a method for estimating allele-specific copy number using whole exome sequencing data from tumor and matched normal.
• VACCINES, CONTAGION, AND SOCIAL NETWORKS AI翻译
  作者：Ogburn, Elizabeth L.; VanderWeele, Tyler J.
  作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Consider the causal effect that one individual's treatment may have on another individual's outcome when the outcome is contagious, with specific application to the effect of vaccination on an infectious disease outcome. The effect of one individual's vaccination on another's outcome can be decomposed into two different causal effects, called the infectiousness and contagion effects. We present identifying assumptions and estimation or testing procedures for infectiousness and contagion effect...
• COVARIATE-ADAPTIVE CLUSTERING OF EXPOSURES FOR AIR POLLUTION EPIDEMIOLOGY COHORTS AI翻译
  作者：Keller, Joshua P.; Drton, Mathias; Larson, Timothy; Kaufman, Joel D.; Sandler, Dale P.; Szpiro, Adam A.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
  摘要：Cohort studies in air pollution epidemiology aim to establish associations between health outcomes and air pollution exposures. Statistical analysis of such associations is complicated by the multivariate nature of the pollutant exposure data as well as the spatial misalignment that arises from the fact that exposure data are collected at regulatory monitoring network locations distinct from cohort locations. We present a novel clustering approach for addressing this challenge. Specifically, w...