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作者：Songdechakraiwut, Tanannun; Chung, Moo K.
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：This paper proposes a novel topological learning framework that integrates networks of different sizes and topology through persistent homology. Such challenging task is made possible through the introduction of a computationally efficient topological loss. The use of the proposed loss bypasses the intrinsic computational bottleneck associated with matching networks. We validate the method in extensive statistical simulations to assess its effectiveness when discriminating networks with differ...
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作者：Schoenberg, Frederic
作者单位：University of California System; University of California Los Angeles
摘要：The question addressed here is whether, using Hawkes models. the distribution of SARS-CoV-2 (Covid-19) transmission times can be estimated accurately with only case-count data. We fit Hawkes models with varying productivities to each of the 50 United States individually, estimating for each state a transmission time density, both nonparametrically and using a normal approximation. We find that, for nearly all states, the estimated transmission times are centered near seven days with a standard...
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作者：Trangucci, Rob; Chen, Yang; Zelner, Jon
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Characterizing the cumulative burden of COVID-19 by race/ethnicity is of the utmost importance for public health researchers and policy makers in order to design effective mitigation measures. This analysis is hampered, however, by surveillance case data with substantial missingness in race and ethnicity covariates. Worse yet, this missingness likely depends on the values of these missing covariates; that is, they are not-missing-at-random (NMAR). We propose a Bayesian parametric model that le...
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作者：Grabski, Isabella N.; De Vito, Roberta; Trippa, Lorenzo; Parmigiani, Giovanni
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Brown University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Mutations in the BRCA1 and BRCA2 genes are known to be highly associated with breast cancer. Identifying both shared and unique transcript expression patterns in blood samples from these groups can shed insight into if and how the disease mechanisms differ among individuals by mutation status, but this is challenging in the high-dimensional setting. A recent method, mon to all studies (or equivalently, groups) and latent factors specific to individual studies. However, BMSFA does not allow for...
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作者：Peterson, Adam T.; Berrocal, Veronica J.; Sanchez-Vaznaugh, Emma V.; Sanchez, Brisa N.
作者单位：University of Michigan System; University of Michigan; University of California System; University of California Irvine; California State University System; San Francisco State University; Drexel University
摘要：Built environment features (BEFs) refer to aspects of the human con-structed environment which may, in turn, support or restrict health related behaviors and thus impact health. In this paper we are interested in under-standing whether the spatial distribution and quantity of fast-food restaurants (FFRs) influence the risk of obesity in schoolchildren. To achieve this goal, we propose a two-stage Bayesian hierarchical modeling framework. In the first stage, examining the position of FFRs relat...
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作者：Allenbrand, Corban; Sherwood, Ben
作者单位：University of Kansas
摘要：Statistical model development is a central feature of many scientific in-vestigations with a vast methodological landscape. However, uncertainty in the model development process has received less attention and is frequently resolved nonrigorously through beliefs about generalizability, practical use-fulness, and computational ease. This is particularly problematic in settings of abundant data, such as clickstream data, as model selection routinely ad-mits multiple models and imposes a source o...
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作者：Zhang, Zhiwei; Hu, Zonghui; Follmann, Dean; Nie, Lei
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH Division of Cancer Treatment & Diagnosis; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); US Food & Drug Administration (FDA)
摘要：Noncompliance is a common intercurrent event in randomized clini-cal trials that raises important questions about analytical objectives and ap-proaches. Motivated by the Multiple Risk Factor Intervention Trial (MRFIT), we consider how to estimate the average treatment effect (ATE) in random-ized trials with all-or-none compliance. Confounding is a major challenge in estimating the ATE, and conventional methods for confounding adjustment typically require the assumption of no unmeasured confoun...
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作者：Lee, Duncan
作者单位：University of Glasgow
摘要：Spatially aggregated disease-count data relating to a set of nonoverlap-ping areal units are often used to make inference on population-level disease risk. This includes the identification of risk boundaries, which are locations where there is a sizeable change in risk between geographically neighbouring areal units. Existing studies provide spatially discrete inference on the areal unit footprint, which forces the boundaries to coincide with the entire geo-graphical border between neighbourin...
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作者：Legrand, Juliette; Ailliot, Pierre; Naveau, Philippe; Raillard, Nicolas
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite Paris Saclay; CEA; Universite Paris Saclay; Universite de Bretagne Occidentale; Ifremer
摘要：The characterisation of future extreme wave events is crucial because of their multiple impacts, covering a broad range of topics such as coastal flood hazard, coastal erosion, reliability of offshore and coastal structures. The main goal of this paper is to propose and study a stochastic simulator that, given offshore conditions (peak direction Dp, peak period Tp and moderately high significant wave heights Hs), produces jointly offshore and coastal ex-treme Hs, a quantity measuring the wave ...
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作者：Zhu, Xiaochen; Slawski, Martin; Tang, Liansheng
作者单位：George Mason University; State University System of Florida; University of Central Florida
摘要：Biometric traits, such as fingerprints, facial images, and teeth impres-sions, are often used in forensic analysis to identify crime suspects. Matching such biometric traits is not perfect, and recent reports have indicated the need for quantifiable measures of error rates for (these) possible matches. Often, comparisons between two sets of a trait are scored with a higher score indi-cating a higher likelihood that the sets are a match. Adjustment of the cutoff for which a match is declared yi...
