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作者：Rubin-Delanchy, Patrick; Heard, Nicholas A.; Lawson, Daniel J.
作者单位：University of Bristol; Imperial College London; University of Bristol
摘要：The mid-p-value is a proposed improvement on the ordinary p-value for the case where the test statistic is partially or completely discrete. In this case, the ordinary p-value is conservative, meaning that its null distribution is larger than a uniform distribution on the unit interval, in the usual stochastic order. The mid-p-value is not conservative. However, its null distribution is dominated by the uniform distribution in a different stochastic order, called the convex order. The property...
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作者：Luo, S.; Song, R.; Styner, M.; Gilmore, J. H.; Zhu, H.
作者单位：North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Texas System; UTMD Anderson Cancer Center
摘要：The aim of this article is to develop a novel class of functional structural equation models (FSEMs) for dissecting functional genetic and environmental effects on twin functional data, while characterizing the varying association between functional data and covariates of interest. We propose a three-stage estimation procedure to estimate varying coefficient functions for various covariates (e.g., gender) as well as three covariance operators for the genetic and environmental effects. We devel...
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作者：Escanciano, J. C.; Goh, S. C.
作者单位：Universidad Carlos III de Madrid; University of Guelph
摘要：Regression quantiles have asymptotic variances that depend on the conditional densities of the response variable given regressors. This article develops a new estimate of the asymptotic variance of regression quantiles that leads any resulting Wald-type test or confidence region to behave as well in large samples as its infeasible counterpart in which the true conditional response densities are embedded. We give explicit guidance on implementing the new variance estimator to control adaptively...
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作者：Tang, Xueying; Yang, Yang; Yu, Hong-Jie; Liao, Qiao-Hong; Bliznyuk, Nikolay
作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Chinese Center for Disease Control & Prevention; State University System of Florida; University of Florida
摘要：Many surveillance systems of infectious diseases are syndrome-based, capturing patients by clinical manifestation. Only a fraction of patients, mostly severe cases, undergo laboratory validation to identify the underlying pathogen. Motivated by the need to understand transmission dynamics and associate risk factors of enteroviruses causing the hand, foot, and mouth disease (HFMD) in China, we developed a Bayesian spatio-temporal modeling framework for surveillance data of infectious diseases w...
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作者：Cao, Yuanpei; Lin, Wei; Li, Hongzhe
作者单位：University of Pennsylvania; Peking University; Peking University
摘要：High-dimensional compositional data arise naturally in many applications such as metagenomic data analysis. The observed data lie in a high-dimensional simplex, and conventional statistical methods often fail to produce sensible results due to the unit-sum constraint. In this article, we address the problem of covariance estimation for high-dimensional compositional data and introduce a composition-adjusted thresholding (COAT) method under the assumption that the basis covariance matrix is spa...
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作者：Mak, Simon; Wu, C. F. Jeff
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：This article introduces a novel method for selecting main effects and a set of reparameterized effects called conditional main effects (CMEs), which capture the conditional effect of a factor at a fixed level of another factor. CMEs represent interpretable, domain-specific phenomena for a wide range of applications in engineering, social sciences, and genomics. The key challenge is in incorporating the implicit grouped structure of CMEs within the variable selection procedure itself. We propos...
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作者：Zhang, Rongmao; Robinson, Peter; Yao, Qiwei
作者单位：Zhejiang University; Zhejiang University; University of London; London School Economics & Political Science; University of London; London School Economics & Political Science; Peking University
摘要：We propose a new and easy-to-use method for identifying cointegrated components of nonstationary time series, consisting of an eigenanalysis for a certain nonnegative definite matrix. Our setting is model-free, and we allow the integer-valued integration orders of the observable series to be unknown, and to possibly differ. Consistency of estimates of the cointegration space and cointegration rank is established both when the dimension of the observable time series is fixed as sample size incr...
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作者：Risser, Mark D.; Paciorek, Christopher J.; Stone, Daithi A.
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：The Weather Risk Attribution Forecast (WRAF) is a forecasting tool that uses output from global climate models to make simultaneous attribution statements about whether and how greenhouse gas emissions have contributed to extreme weather across the globe. However, in conducting a large number of simultaneous hypothesis tests, the WRAF is prone to identifying false discoveries. A common technique for addressing this multiple testing problem is to adjust the procedure in a way that controls the ...
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作者：Wang, Jingshu; Owen, Art B.
作者单位：University of Pennsylvania; Stanford University
摘要：Meta-analysis combines results from multiple studies aiming to increase power in finding their common effect. It would typically reject the null hypothesis of no effect if any one of the studies shows strong significance. The partial conjunction null hypothesis is rejected only when at least r of n component hypotheses are nonnull with r = 1 corresponding to a usual meta-analysis. Compared with meta-analysis, it can encourage replicable findings across studies. A by-product of it when applied ...
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作者：Basu, Pallavi; Cai, T. Tony; Das, Kiranmoy; Sun, Wenguang
作者单位：Tel Aviv University; University of Pennsylvania; Indian Statistical Institute; Indian Statistical Institute Kolkata; University of Southern California
摘要：The use of weights provides an effective strategy to incorporate prior domain knowledge in large-scale inference. This article studies weighted multiple testing in a decision-theoretical framework. We develop oracle and data-driven procedures that aim to maximize the expected number of true positives subject to a constraint on the weighted false discovery rate. The asymptotic validity and optimality of the proposed methods are established. The results demonstrate that incorporating informative...
