2024

最新文章

• Evolution is not driven by and toward increasing information and complexity AI翻译
  作者：Root-Bernstein, Meredith
  作者单位：Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS)
• Disorder- to- order active site capping regulates the rate- limiting step of the inositol pathway AI翻译
  作者：Traeger, Toni K.; Kyrilis, Fotis L.; Hamdi, Farzad; Tueting, Christian; Alfes, Marie; Hofmann, Tommy; Schmidt, Carla; Kastritis, Panagiotis L.
  作者单位：Martin Luther University Halle Wittenberg; Martin Luther University Halle Wittenberg; National Hellenic Research Foundation; Martin Luther University Halle Wittenberg; AbbVie; Johannes Gutenberg University of Mainz
  摘要：Myo- inositol-1- phosphate synthase (MIPS) catalyzes the NAD+- dependent isomerization of glucose- 6- phosphate (G6P) into inositol-1- phosphate (IMP), controlling the rate- limiting step of the inositol pathway. Previous structural studies focused on the detailed molecular mechanism, neglecting large- scale conformational changes that drive the function of this 240 kDa homotetrameric complex. In this study, we identified the active, endogenous MIPS in cell extracts from the thermophilic fungu...
• ZNF91 is an endogenous repressor of the molecular phenotype associated with X- linked dystonia-parkinsonism (XDP) AI翻译
  作者：Rosenkrantz, Jimi L.; Brandorff, J. Elias; Raghib, Sanaz; Kapadia, Ashni; Vaine, Christine A.; Bragg, D. Cristopher; Farmiloe, Grace; Jacobs, Frank M. J.
  作者单位：University of Amsterdam; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Amsterdam; Vrije Universiteit Amsterdam
  摘要：X- linked dystonia-parkinsonism (XDP) is a severe neurodegenerative disorder resulting from an inherited intronic SINE-Alu-VNTR (SVA) retrotransposon in the TAF1 gene that causes dysregulation of TAF1 transcription. The specific mechanism underlying this dysregulation remains unclear, but it is hypothesized to involve the formation of G- quadruplexes (G4) structures within the XDP-SVA that impede transcription. In this study, we show that ZNF91, a critical repressor of SVA retrotransposons, sp...
• Climate change and California sustainability-Challenges and solutions AI翻译
  作者：Franklin, Janet; Macdonald, Glen M.
  作者单位：California State University System; San Diego State University; University of California System; University of California Los Angeles
• Fragment correlation mass spectrometry: Determining the structures of biopolymers in a complex mixture without isolating individual components AI翻译
  作者：Li, Yangjie; Cavet, Guy; Zare, Richard N.; Driver, Taran
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：Fragment correlation mass spectrometry correlates ion pairs generated from the same fragmentation pathway, achieved by covariance mapping of tandem mass spectra generated with an unmodified linear ion trap without preseparation. We enable the identification of different precursors at different charge states in a complex mixture from a large isolation window, empowering an analytical approach for data- independent acquisition. The method resolves and matches isobaric fragments, internal ions, a...
• Active regulation of amyloidosis AI翻译
  作者：Lin, Yi
  作者单位：Tsinghua University
• Competing adaptations maintain nonadaptive variation in a wild cricket population AI翻译
  作者：Rayner, Jack G.; Eichenberger, Franca; Bainbridge, Jessica V. A.; Zhang, Shangzhe; Zhang, Xiao; Yusuf, Leeban H.; Balenger, Susan; Gaggiotti, Oscar E.; Bailey, Nathan W.
  作者单位：University System of Maryland; University of Maryland College Park; University of St Andrews; University of Lausanne; Tianjin Normal University; University of Minnesota System; University of Minnesota Twin Cities
  摘要：How emerging adaptive variants interact is an important factor in the evolution of wild populations, but the opportunity to empirically study this interaction is rare. We recently documented the emergence of an adaptive phenotype curly- wing in Hawaiian populations of field crickets ( Teleogryllus oceanicus). Curly- wing inhibits males' ability to sing, protecting them from eavesdropping parasitoid flies ( Ormia ochracea). Surprisingly, curly- wing co- occurs with similarly protective silent f...
• Elucidating the roles of electrolytes and hydrogen bonding in the dewetting dynamics of the tear film AI翻译
  作者：Borkar, Suraj; Baumli, Philipp; Vance, Travis; Sharma, Ekta; Shi, Xinfeng; Wu, James Y.; Yao, George; Myung, David; Fuller, Gerald G.
  作者单位：Stanford University; Stanford University
  摘要：This study explores the impact of electrostatic interactions and hydrogen bonding on tear film stability, a crucial factor for ocular surface health. While mucosal and meibomian layers have been extensively studied, the role of electrolytes in the aqueous phase remains unclear. Dry eye syndrome, characterized by insufficient tear quantity or quality, is associated with hyperosmolality, making electrolyte composition an important factor that might impact tear stability. Using a model buffer sol...
• Kinesin-1-transported liposomes prefer to go straight in 3D microtubule intersections by a mechanism shared by other molecular motors AI翻译
  作者：Bensel, Brandon M.; Previs, Samantha Beck; Bookwalter, Carol; Trybus, Kathleen M.; Walcott, Sam; Warshaw, David M.
  作者单位：University of Vermont; Worcester Polytechnic Institute
  摘要：Kinesin-1 ensembles maneuver vesicular cargoes through the three-dimensional (3D) intracellular microtubule (MT) network. To define how such cargoes navigate MT intersections, we first determined how many kinesins from an ensemble on a lipid-based cargo simultaneously engage a MT, and then determined the directional outcomes (straight, turn, terminate) for liposome cargoes at perpendicular MT intersections. Run lengths of 350-nm diameter liposomes decorated with up to 20, constitutively active...
• Profile of Alexei I. Ekimov, Louis E. Brus, and Moungi G. Bawendi: 2023 Nobel laureates in chemistry AI翻译
  作者：Manna, Liberato; Odom, Teri W.