6627期

最新文章

• Machine learning-aided real-time detection of keyhole pore generation in laser powder bed fusion AI翻译
  作者：Ren, Zhongshu; Gao, Lin; Clark, Samuel J.; Fezzaa, Kamel; Shevchenko, Pavel; Choi, Ann; Everhart, Wes; Rollett, Anthony D.; Chen, Lianyi; Sun, Tao
  作者单位：University of Virginia; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Honeywell; Carnegie Mellon University; University of Wisconsin System; University of Wisconsin Madison
  摘要：Porosity defects are currently a major factor that hinders the widespread adoption of laser-based metal additive manufacturing technologies. One common porosity occurs when an unstable vapor depression zone (keyhole) forms because of excess laser energy input. With simultaneous high-speed synchrotron x-ray imaging and thermal imaging, coupled with multiphysics simulations, we discovered two types of keyhole oscillation in laser powder bed fusion of Ti-6Al-4V. Amplifying this understanding with...
• Interdisciplinary collaboration AI翻译
  作者：Singh, Garima
• Supportive relationships AI翻译
  作者：Tan, Bryce W. Q.
  作者单位：National University of Singapore
• New research avenues AI翻译
  作者：Tan, Bryce W. Q.
  作者单位：National University of Singapore
• A bid to end mpox AI翻译
  作者：Brainard, Jeffrey
• Obesity confers macrophage memory Epigenetic programming of myeloid cells in obesity contributes to macular degeneration AI翻译
  作者：Mangum, Kevin D.; Gallagher, Katherine A.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
• AREAS TO WATCH: WHAT TO EXPECT IN RESEARCH AND POLICY Science strives to keep up with an evolving coronavirus AI翻译
  作者：Brainard, Jeffrey
• Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry AI翻译
  作者：Djenoune, Lydia; Mahamdeh, Mohammed; V. Truong, Thai; Nguyen, Christopher T.; Fraser, Scott E.; Brueckner, Martina; Howard, Jonathon; Yuan, Shiaulou
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Cleveland Clinic Foundation; Massachusetts Institute of Technology (MIT); Yale University; Yale University
  摘要：The breaking of bilateral symmetry in most vertebrates is critically dependent upon the motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid flow; however, it remains unclear how this flow is sensed. Here, we demonstrated that immotile LRO cilia are mechanosensors for shear force using a methodological pipeline that combines optical tweezers, light sheet microscopy, and deep learning to permit in vivo analyses in zebrafish. Mechanical manipulation of imm...
• Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation AI翻译
  作者：Hata, Masayuki; Andriessen, Elisabeth M. M. A.; Hata, Maki; Diaz-Marin, Roberto; Fournier, Frederik; Crespo-Garcia, Sergio; Blot, Guillaume; Juneau, Rachel; Pilon, Frederique; Dejda, Agnieszka; Guber, Vera; Heckel, Emilie; Daneault, Caroline; Calderon, Virginie; Des Rosiers, Christine; Melichar, Heather J.; Langmann, Thomas; Joyal, Jean-Sebastien; Wilson, Ariel M.; Sapieha, Przemyslaw
  作者单位：Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Universite de Montreal; University of Cologne; University of Cologne
  摘要：Age-related macular degeneration is a prevalent neuroinflammatory condition and a major cause of blindness driven by genetic and environmental factors such as obesity. In diseases of aging, modifiable factors can be compounded over the life span. We report that diet-induced obesity earlier in life triggers persistent reprogramming of the innate immune system, lasting long after normalization of metabolic abnormalities. Stearic acid, acting through Toll-like receptor 4 (TLR4), is sufficient to ...
• Supportive relationships AI翻译
  作者：Powell, Jackson Ross
  作者单位：University of Pennsylvania