6635期

最新文章

• DO NO UNCONSCIOUS HARM AI翻译
  作者：Ortega, Rodrigo Perez
  摘要：Implicit bias can degrade health care. Now, researchers are finding new ways to recognize and mitigate it
• UK-EU deal opens door to science funds AI翻译
  作者：Brainard, Jeffrey
• USB1 is a miRNA deadenylase that regulates hematopoietic development AI翻译
  作者：Jeong, Ho-Chang; Shukla, Siddharth; Fok, Wilson Chun; Huynh, Thao Ngoc; Batista, Luis Francisco Zirnberger; Parker, Roy
  作者单位：Washington University (WUSTL); Siteman Cancer Center; Washington University (WUSTL); University of Colorado System; University of Colorado Boulder; Howard Hughes Medical Institute
  摘要：Mutations in the 3' to 5' RNA exonuclease USB1 cause hematopoietic failure in poikiloderma with neutropenia (PN). Although USB1 is known to regulate U6 small nuclear RNA maturation, the molecular mechanism underlying PN remains undetermined, as pre-mRNA splicing is unaffected in patients. We generated human embryonic stem cells harboring the PN-associated mutation c.531_delA in USB1 and show that this mutation impairs human hematopoiesis. Dysregulated microRNA (miRNA) levels in USB1 mutants du...
• Lab pauses monkey imports AI翻译
  作者：Brainard, Jeffrey
• Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis AI翻译
  作者：Rossler, Simon L.; Grob, Nathalie M.; Buchwald, Stephen L.; Pentelute, Bradley L.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide-based encoding is hampered by inherent limitations of information stability and density. In this study, we establish abiotic peptides for next-generation information storage and apply them for the encoding of diverse small-molecule synthesis. The chemical stability of the peptide-based tag allows the use of palladium-mediated re...
• Wealth gap in biomedical research is growing AI翻译
  作者：Kaiser, Jocelyn
  摘要：Women and Black researchers are less likely to hold multiple NIH grants
• The Pod Generation AI翻译
  作者：Dominy, Nathaniel J.
• Embryo-editing scientist loses visa AI翻译
  作者：Brainard, Jeffrey
• Ecosystem-based management outperforms species-focused stocking for enhancing fish populations AI翻译
  作者：Radinger, Johannes; Matern, Sven; Klefoth, Thomas; Wolter, Christian; Feldhege, Fritz; Monk, Christopher T.; Arlinghaus, Robert
  作者单位：Leibniz Association; Leibniz Institut fur Gewasserokologie und Binnenfischerei (IGB); Humboldt University of Berlin; Bremen University of Applied Sciences; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Humboldt University of Berlin
  摘要：Ecosystem-based management is costly. Therefore, without rigorously showing that it can outperform traditional species-focused alternatives, its broad-scale adoption in conservation is unlikely. We present a large-scale replicated and controlled set of whole-lake experiments in fish conservation (20 lakes monitored over 6 years with more than 150,000 fish sampled) to examine the outcomes of ecosystem-based habitat enhancement (coarse woody habitat addition and shallow littoral zone creation) v...
• Potential of China's offshore wind energy AI翻译
  作者：Xia, Siyou; Yang, Yu; Liu, Yi
  作者单位：Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS