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作者：Brainard, Jeffrey
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作者：Zdenek, Christina N.
作者单位：University of Queensland
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作者：Castellani, Giulia; Croese, Tommaso; Ramos, Javier M. Peralta; Schwartz, Michal
作者单位：Weizmann Institute of Science
摘要：Contemporary studies have completely changed the view of brain immunity from envisioning the brain as isolated and inaccessible to peripheral immune cells to an organ in close physical and functional communication with the immune system for its maintenance, function, and repair. Circulating immune cells reside in special niches in the brain's borders, the choroid plexus, meninges, and perivascular spaces, from which they patrol and sense the brain in a remote manner. These niches, together wit...
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作者：Shrock, Ellen L.; Timms, Richard T.; Kula, Tomasz; Mena, Elijah L.; West Jr, Anthony P.; Guo, Rui; Lee, I-Hsiu; Cohen, Alexander A.; McKay, Lindsay G. A.; Bi, Caihong; Keerti; Leng, Yumei; Fujimura, Eric; Horns, Felix; Li, Mamie; Wesemann, Duane R.; Griffiths, Anthony; Gewurz, Benjamin E.; Bjorkman, Pamela J.; Elledge, Stephen J.
作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; University of Cambridge; California Institute of Technology; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Boston University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Chan Zuckerberg Initiative (CZI); Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Ragon Institute; Harvard University; Harvard Medical School; Harvard University
摘要：Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant public epitopes at high resolution and characterizing several of their cognate antibodies, we concluded that germline-encoded sequences in antibodies drive recurrent recognition. Systematic analysis of antibody-antigen structures uncovered...
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作者：Ossiander, Marcus; Meretska, Maryna Leonidivna; Hampel, Hana Kristin; Lim, Soon Wei Daniel; Knefz, Nico; Jauk, Thomas; Capasso, Federico; Schultze, Martin
作者单位：Harvard University; Graz University of Technology
摘要：Extreme ultraviolet (EUV) radiation is a key technology for material science, attosecond metrology, and lithography. Here, we experimentally demonstrate metasurfaces as a superior way to focus EUV light. These devices exploit the fact that holes in a silicon membrane have a considerably larger refractive index than the surrounding material and efficiently vacuum-guide light with a wavelength of similar to 50 nanometers. This allows the transmission phase at the nanoscale to be controlled by th...
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作者：Mao, Chunyou; Xiao, Peng; Tao, Xiao-Na; Qin, Jiao; He, Qing-Tao; Zhang, Chao; Guo, Sheng-Chao; Du, Ya-Qin; Chen, Li-Nan; Shen, Dan-Dan; Yang, Zhi-Shuai; Zhang, Han-Qiong; Huang, Shen-Ming; He, Yong-Hao; Cheng, Jie; Zhong, Ya-Ni; Shang, Pan; Chen, Jun; Zhang, Dao-Lai; Wang, Qian-Lang; Liu, Mei-Xia; Li, Guo-Yu; Guo, Yongyuan; Xu, H. Eric; Wang, Chuanxin; Zhang, Cheng; Feng, Shiqing; Yu, Xiao; Zhang, Yan; Sun, Jin-Peng
作者单位：Zhejiang University; Zhejiang University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Binzhou Medical University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Shandong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Shandong University; Zhejiang University; Liangzhu Laboratory; Zhejiang University
摘要：Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through engagement with more than 40G protein-coupled receptors. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification of GPR120, which is involved in a spectrum of metabolic diseases. Here, we report six cryo-electron microscopy structures of GPR120 in complex with FA hormones or TUG891 and Gi or Giq trimers. Aromatic residues inside the GPR120 ligand pocket were resp...
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作者：Darras, H.; Berney, C.; Hasin, S.; Drescher, J.; Feldhaar, H.; Keller, L.
作者单位：Johannes Gutenberg University of Mainz; University of Lausanne; Valaya Alongkorn Rajabhat University; University of Gottingen; University of Bayreuth
摘要：Multicellular organisms typically develop from a single fertilized egg and therefore consist of clonal cells. We report an extraordinary reproductive system in the yellow crazy ant. Males are chimeras of haploid cells from two divergent lineages: R and W. R cells are overrepresented in the males' somatic tissues, whereas W cells are overrepresented in their sperm. Chimerism occurs when parental nuclei bypass syngamy and divide separately within the same egg. When syngamy takes place, the diplo...
