Transforming the understanding of brain immunity

• 成果类型: Review
• 署名作者: Castellani, Giulia; Croese, Tommaso; Ramos, Javier M. Peralta; Schwartz, Michal
• 署名单位: Weizmann Institute of Science
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10284
• DOI: 10.1126/science.abo7649
• 发表日期: 2023-04-01
• 关键词: central-nervous-system; adult hippocampal neurogenesis; choroid-plexus; t-cells; mouse model; perivascular macrophages; cerebrospinal-fluid; cognitive dysfunction; disease progression; parkinsons-disease

摘要

Contemporary studies have completely changed the view of brain immunity from envisioning the brain as isolated and inaccessible to peripheral immune cells to an organ in close physical and functional communication with the immune system for its maintenance, function, and repair. Circulating immune cells reside in special niches in the brain's borders, the choroid plexus, meninges, and perivascular spaces, from which they patrol and sense the brain in a remote manner. These niches, together with the meningeal lymphatic system and skull microchannels, provide multiple routes of interaction between the brain and the immune system, in addition to the blood vasculature. In this Review, we describe current ideas about brain immunity and their implications for brain aging, diseases, and immune-based therapeutic approaches.