6647期

最新文章

• Proteasome cap particle regulates synapses AI翻译
  作者：Turker, Fulya; Margolis, Seth S.
  作者单位：Johns Hopkins University; Johns Hopkins University
• Correlated insulator of excitons in WSe2/WS2 moire superlattices AI翻译
  作者：Xiong, Richen; Nie, Jacob H.; Brantly, Samuel L.; Hays, Patrick; Sailus, Renee; Watanabe, Kenji; Taniguchi, Takashi; Tongay, Sefaattin; Jin, Chenhao
  作者单位：University of California System; University of California Santa Barbara; Arizona State University; Arizona State University-Tempe; National Institute for Materials Science; National Institute for Materials Science
  摘要：A panoply of unconventional electronic states has been observed in moire superlattices. Engineering similar bosonic phases remains, however, largely unexplored. We report the observation of a bosonic correlated insulator in tungsten diselenide/tungs ten disulfide (WSe2/WS2) moire superlattices composed of excitons, that is, tightly bound electron-hole pairs. We develop a pump probe spectroscopy method that we use to observe an exciton incompressible state at exciton filling nex = 1 and charge ...
• Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse AI翻译
  作者：Stinchcombe, Jane C.; Asano, Yukako; Kaufman, Christopher J. G.; Bohlig, Kristin; Peddie, Christopher J.; Collinson, Lucy M.; Nadler, Andre; Griffiths, Gillian M.
  作者单位：University of Cambridge; Max Planck Society; Francis Crick Institute
  摘要：Cytotoxic T lymphocytes (CTLs) kill virus-infected and cancer cells through T cell receptor (TCR) recognition. How CTLs terminate signaling and disengage to allow serial killing has remained a mystery. TCR activation triggers membrane specialization within the immune synapse, including the production of diacylglycerol (DAG), a lipid that can induce negative membrane curvature. We found that activated TCRs were shed into DAG-enriched ectosomes at the immune synapse rather than internalized thro...
• NUCLEAR SECURITY US planning test reactor to run on weapons-grade uranium AI翻译
  作者：Cho, Adrian
• Mpox vaccine shows protection AI翻译
  作者：[Anonymous]
• An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses AI翻译
  作者：Sun, Chao; Desch, Kristina; Nassim-Assir, Belquis; Giandomenico, Stefano L.; Nemcova, Paulina; Langer, Julian D.; Schuman, Erin M.
  作者单位：Max Planck Society; Max Planck Society; Aarhus University; University of Bonn
  摘要：The proteasome, the major protein-degradation machine in cells, regulates neuronal synapses and long-term information storage. Here, using super-resolution microscopy, we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles, are differentially distributed within individual rat cortical neurons. We discovered an unexpected abundance of free 19S particles near synapses. The free neuronal 19S particles bind and deubiquitylate lysine 63-ub...
• Cancer trials move goal posts AI翻译
  作者：[Anonymous]
• Fire Weather: A True Story from a Hotter World AI翻译
  作者：Boon, Sarah
• Plainly fixing crystal lattices AI翻译
  作者：Chung, In
  作者单位：Seoul National University (SNU); Institute for Basic Science - Korea (IBS)
  摘要：A thermoelectric alloy achieves high performance in electronic cooling
• PUBLIC HEALTH FDA advisers back maternal RSV shot AI翻译
  作者：Brainard, Jeffrey