作者：Li, Nan; Li, Yang; Cheng, Zhe; Liu, Youdi; Dai, Yahao; Kang, Seounghun; Li, Songsong; Shan, Naisong; Wai, Shinya; Ziaja, Aidan; Wang, Yunfei; Strzalka, Joseph; Liu, Wei; Zhang, Cheng; Gu, Xiaodan; Hubbell, Jeffrey A.; Tian, Bozhi; Wang, Sihong
作者单位：University of Chicago; University of Chicago; University of Southern Mississippi; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory
摘要：The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type bioelectronic devices, the semiconductors that need to have direct interfacing with biotissues for effective signal transduction do not adhere well with wet tissues, thereby limiting the stability and conformability at the interface. We report a bioadhesive polymer semiconductor through a double-network structure formed by a bioadhesive brush polymer and a redox-active semiconducting polymer. Th...
作者：Park, Jiwoong
作者单位：University of Chicago; University of Chicago
作者：Ash, Caroline; Lopez, Bianca; Uzogara, Ekeoma E.; Vignieri, Sacha
作者：McAfee, Dominic; Connell, Sean D.
作者单位：University of Adelaide; University of Adelaide
作者：Brambati, Alessandra; Sacco, Olivia; Porcella, Sarina; Heyza, Joshua; Kareh, Mike; Schmidt, Jens C.; Sfeir, Agnel
作者单位：Memorial Sloan Kettering Cancer Center; Michigan State University; Michigan State University
摘要：Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas microhomology-mediated end-joining (MMEJ) has been regarded as a backup mechanism. Through CRISPR-Cas9-based synthetic lethal screens in cancer cells, we identified subunits of the 9-1-1 complex (RAD9A-RAD1-HUS1) and its interacting partner, RHINO, as crucial MMEJ factors. We uncovered an unexpected function for RHINO in restrictin...
