Bioadhesive polymer semiconductors and transistors for intimate biointerfaces

• 成果类型: Article
• 署名作者: Li, Nan; Li, Yang; Cheng, Zhe; Liu, Youdi; Dai, Yahao; Kang, Seounghun; Li, Songsong; Shan, Naisong; Wai, Shinya; Ziaja, Aidan; Wang, Yunfei; Strzalka, Joseph; Liu, Wei; Zhang, Cheng; Gu, Xiaodan; Hubbell, Jeffrey A.; Tian, Bozhi; Wang, Sihong
• 署名单位: University of Chicago; University of Chicago; University of Southern Mississippi; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11275
• DOI: 10.1126/science.adg8758
• 发表日期: 2023-08-11
• 页码: 686-+
• 关键词: tough; adhesion; films

摘要

The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type bioelectronic devices, the semiconductors that need to have direct interfacing with biotissues for effective signal transduction do not adhere well with wet tissues, thereby limiting the stability and conformability at the interface. We report a bioadhesive polymer semiconductor through a double-network structure formed by a bioadhesive brush polymer and a redox-active semiconducting polymer. The resulting semiconducting film can form rapid and strong adhesion with wet tissue surfaces together with high charge-carrier mobility of similar to 1 square centimeter per volt per second, high stretchability, and good biocompatibility. Further fabrication of a fully bioadhesive transistor sensor enabled us to produce high-quality and stable electrophysiological recordings on an isolated rat heart and in vivo rat muscles.