6663期

最新文章

• Mars Sample Return risks consuming NASA science AI翻译
  作者：Voosen, Paul
• The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase AI翻译
  作者：Medoh, Uche N.; Hims, Andy; Chen, Julie Y.; Ghoochani, Ali; Nyame, Kwamina; Dong, Wentao; Abu-Remaileh, Monther
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Lysosomes critically rely on bis(monoacylglycero)phosphate (BMP) to stimulate lipid catabolism, cholesterol homeostasis, and lysosomal function. Alterations in BMP levels in monogenic and complex neurodegeneration suggest an essential function in human health. However, the site and mechanism responsible for BMP synthesis have been subject to debate for decades. Here, we report that the Batten disease gene product CLN5 is the elusive BMP synthase (BMPS). BMPS-deficient cells exhibited a massive...
• MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease AI翻译
  作者：Balusu, Sriram; Horre, Katrien; Thrupp, Nicola; Craessaerts, Katleen; Snellinx, An; Serneels, Lutgarde; T'Syen, Dries; Chrysidou, Iordana; Arranz, Amaia M.; Sierksma, Annerieke; Simren, Joel; Karikari, Thomas K.; Zetterberg, Henrik; Chen, Wei-Ting; Thal, Dietmar Rudolf; Salta, Evgenia; Fiers, Mark; De Strooper, Bart
  作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; Basque Foundation for Science; Sahlgrenska University Hospital; University of Gothenburg; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of London; University College London; University of London; University College London; KU Leuven; KU Leuven; University Hospital Leuven; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW)
  摘要：Neuronal cell loss is a defining feature of Alzheimer's disease (AD), but the underlying mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a mouse model of AD. Only human neurons displayed tangles, Gallyas silver staining, granulovacuolar neurodegeneration (GVD), phosphorylated tau blood biomarkers, and considerable neuronal cell loss. The long noncoding RNA MEG3 was strongly up-regulated in human neurons. This neuron-specific long noncoding RNA is also up-regu...
• EU research chief confirmed AI翻译
  作者：Brainard, Jeffrey
• UK finally rejoins Horizon Europe AI翻译
  作者：O'Grady, Cathleen
• Chemically fueling new microrobot abilities AI翻译
  作者：Truby, Ryan L.
  作者单位：Northwestern University; Northwestern University; Northwestern University
• Iran's petrochemical plant affects wetlands AI翻译
  作者：Asghari, Morteza; Salahshoori, Iman
  作者单位：University of Science & Technology of Mazandaran; Iran Polymer & Petrochemical Institute; Islamic Azad University
• Protection from inflammatory bowel disease AI翻译
  作者：Galipeau, Heather J.; Verdu, Elena F.
• Powerful, soft combustion actuators for insect-scale robots AI翻译
  作者：Aubin, Cameron A.; Heisser, Ronald H.; Peretz, Ofek; Timko, Julia; Lo, Jacqueline; Helbling, E. Farrell; Sobhani, Sadaf; Gat, Amir D.; Shepherd, Robert F.
  作者单位：Cornell University; Technion Israel Institute of Technology; Cornell University
  摘要：Insects perform feats of strength and endurance that belie their small stature. Insect-scale robots-although subject to the same scaling laws-demonstrate reduced performance because existing microactuator technologies are driven by low-energy density power sources and produce small forces and/or displacements. The use of high-energy density chemical fuels to power small, soft actuators represents a possible solution. We demonstrate a 325-milligram soft combustion microactuator that can achieve...
• Germany makes up with Elsevier AI翻译
  作者：Brainard, Jeffrey