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作者:Cao, Bo
作者单位:Xi'an Jiaotong University
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作者:Cho, Adrian; Clery, Daniel
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作者:Khan, Muhammad Shehryar
作者单位:Massachusetts Institute of Technology (MIT)
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作者:Curry, Andrew
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作者:[Anonymous]
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作者:[Anonymous]
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作者:Fisch, Daniel; Pfleiderer, Moritz M.; Anastasakou, Eleni; Mackie, Gillian M.; Wendt, Fabian; Liu, Xiangyang; Clough, Barbara; Lara-Reyna, Samuel; Encheva, Vesela; Snijders, Ambrosius P.; Bando, Hironori; Yamamoto, Masahiro; Beggs, Andrew D.; Mercer, Jason; Shenoy, Avinash R.; Wollscheid, Bernd; Maslowski, Kendle M.; Galej, Wojtek P.; Frickel, Eva-Maria
作者单位:Francis Crick Institute; University of Birmingham; European Molecular Biology Laboratory (EMBL); University of Birmingham; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; Francis Crick Institute; University of Osaka; University of Osaka; University of Birmingham; Imperial College London; Francis Crick Institute; University of Birmingham; Beatson Institute; University of Glasgow
摘要:Disruption of cellular activities by pathogen virulence factors can trigger innate immune responses. Interferon-gamma (IFN-gamma)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular pathogens and by inducing programmed cell death. Working in human macrophages, we discovered that GBP1 expression in the absence of IFN-gamma killed the cells and induced Golgi fragmentation. IFN-gamma exposure improved macrophage...
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作者:Pigati, Jeffrey S.; Springer, Kathleen B.; Honke, Jeffrey S.; Wahl, David; Champagne, Marie R.; Zimmerman, Susan R. H.; Gray, Harrison J.; Santucci, Vincent L.; Odess, Daniel; Bustos, David; Bennett, Matthew R.
作者单位:United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of the Interior; US National Park Service; United States Department of the Interior; US National Park Service; United States Department of the Interior; US National Park Service; Bournemouth University
摘要:Human footprints at White Sands National Park, New Mexico, USA, reportedly date to between similar to 23,000 and 21,000 years ago according to radiocarbon dating of seeds from the aquatic plant Ruppia cirrhosa. These ages remain controversial because of potential old carbon reservoir effects that could compromise their accuracy. We present new calibrated 14C ages of terrestrial pollen collected from the same stratigraphic horizons as those of the Ruppia seeds, along with optically stimulated l...
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作者:Powell, Jackson Ross
作者单位:University of Pennsylvania
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作者:Garisto, Dan