6668期

最新文章

• US hands out $7 billion for hydrogen hubs AI翻译
  作者：Bourzac, Katherine
• Giant European scope rises as US rivals stumble AI翻译
  作者：Clery, Daniel
• News at a glance AI翻译
  作者：Brainard, Jeffrey
• Associative and predictive hippocampal codes support memory-guided behaviors AI翻译
  作者：Liu, Can; Todorova, Ralitsa; Tang, Wenbo; Oliva, Azahara; Fernandez-Ruiz, Antonio
  作者单位：Cornell University
  摘要：Episodic memory involves learning and recalling associations between items and their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions to be made. The mechanisms that support these associative and predictive aspects of memory are not yet understood. In this study, we used an optogenetic manipulation to perturb the sequential structure, but not global network dynamics, of place cells as rats traversed specific spatial tra...
• Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size AI翻译
  作者：Aguirre, Lyndsey; Hendelman, Anat; Hutton, Samuel F.; McCandlish, David M.; Lippman, Zachary B.
  作者单位：Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; State University System of Florida; University of Florida; Cold Spring Harbor Laboratory; Howard Hughes Medical Institute
  摘要：Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively. In this study, we used natural and engineered cis-regulatory alleles in a plant stem-cell circuit to systematically evaluate epistatic relationships controlling tomato fruit size. Combining a promoter allelic series with two other loci, we collected over 30,000 phenotypic data poi...
• Phage therapy in noncommunicable diseases AI翻译
  作者：Kviatcovsky, Denise; Valdes-Mas, Rafael; Federici, Sara; Elinav, Eran
  作者单位：Weizmann Institute of Science; Helmholtz Association; German Cancer Research Center (DKFZ)
• Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras AI翻译
  作者：Ahn, Green; Riley, Nicholas M.; Kamber, Roarke A.; Wisnovsky, Simon; von Hase, Salvador Moncayo; Bassik, Michael C.; Banik, Steven M.; Bertozzi, Carolyn R.
  作者单位：Stanford University; Stanford University; Stanford University; University of British Columbia; Stanford University; Howard Hughes Medical Institute
  摘要：Targeted protein degradation can provide advantages over inhibition approaches in the development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to direct extracellular proteins to lysosomes. In this work, we used a genome-wide CRISPR knockout approach to identify modulators of LYTAC-mediated membrane protein degradation in human cells. We found that disrupting retromer genes improved tar...