6677期

最新文章

• San Andreas fault may shake less than once feared AI翻译
  作者：Voosen, Paul
  摘要：Precariously balanced rocks near Los Angeles hold clues to the hazard of a giant earthquake
• Before tunnel collapse, scientists sent warnings AI翻译
  作者：Parvaiz, Athar
  摘要：Researchers repeatedly raised concerns about building in Himalayas' unstable geology
• Iran's Zayandeh Rud River basin in crisis AI翻译
  作者：Salahshoori, Iman; Namayandeh Jorabchi, Majid
  作者单位：Iran Polymer & Petrochemical Institute; Islamic Azad University; Leibniz Association; Leibniz Institut fur Katalyse e.V. an der Universitat Rostock (LIKAT)
• Endel Tulving (1927-2023) AI翻译
  作者：Cabeza, Roberto; Duezel, Emrah
  作者单位：Duke University; Humboldt University of Berlin; Otto von Guericke University; University of London; University College London
• Making a digital dupe of Anderson Cooper AI翻译
  作者：Dickman, Jamie; Farid, Hany; Bohacek, Maty
  作者单位：Northwestern University
  摘要：Two computer scientists discuss deepfakes and how they made a facsimile of the anchor Two computer scientists discuss deepfakes and how they made a facsimile of the anchor
• Biomimetic, knittable aerogel fiber for thermal insulation textile AI翻译
  作者：Wu, Mingrui; Shao, Ziyu; Zhao, Nifang; Zhang, Rongzhen; Yuan, Guodong; Tian, Lulu; Zhang, Zibei; Gao, Weiwei; Bai, Hao
  作者单位：Zhejiang University; Zhejiang University
  摘要：Aerogels have been considered as an ideal material for thermal insulation. Unfortunately, their application in textiles is greatly limited by their fragility and poor processability. We overcame these issues by encapsulating the aerogel fiber with a stretchable layer, mimicking the core-shell structure of polar bear hair. Despite its high internal porosity over 90%, our fiber is stretchable up to 1000% strain, which is greatly improved compared with that of traditional aerogel fibers (similar ...
• Structural visualization of transcription initiation in action AI翻译
  作者：Chen, Xizi; Liu, Weida; Wang, Qianmin; Wang, Xinxin; Ren, Yulei; Qu, Xuechun; Li, Wanjun; Xu, Yanhui
  作者单位：Fudan University; Fudan University; Fudan University
  摘要：Transcription initiation is a complex process, and its mechanism is incompletely understood. We determined the structures of de novo transcribing complexes TC2 to TC17 with RNA polymerase II halted on G-less promoters when nascent RNAs reach 2 to 17 nucleotides in length, respectively. Connecting these structures generated a movie and a working model. As initially synthesized RNA grows, general transcription factors (GTFs) remain bound to the promoter and the transcription bubble expands. Nucl...
• GluD1 binds GABA and controls inhibitory plasticity AI翻译
  作者：Piot, Laura; Heroven, Christina; Bossi, Simon; Zamith, Joseph; Malinauskas, Tomas; Johnson, Chris; Wennagel, Doris; Stroebel, David; Charrier, Cecile; Aricescu, A. Radu; Mony, Laetitia; Paoletti, Pierre
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); MRC Laboratory Molecular Biology; University of Oxford; Wellcome Centre for Human Genetics; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford
  摘要：Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A gamma-aminobutyric acid receptors (GABAARs), which are responsible for neuronal inhibition. However, the GluD1 receptor, an iGluR family member, is present at both excitatory and inhibitory synapses. Whether and how GluD1 activation may affect inhibitory neurotransmission is unknown. In this work, by using a combinatio...
• Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2 AI翻译
  作者：Zhu, Hanwen; Tonelli, Francesca; Turk, Martin; Prescott, Alan; Alessi, Dario R.; Sun, Ji
  作者单位：St Jude Children's Research Hospital; University of Dundee; St Jude Children's Research Hospital
  摘要：Gain-of-function mutations in LRRK2, which encodes the leucine-rich repeat kinase 2 (LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is recruited to membrane organelles and activated by Rab29, a Rab guanosine triphosphatase encoded in the PARK16 locus. We present cryo-electron microscopy structures of Rab29-LRRK2 complexes in three oligomeric states, providing key snapshots during LRRK2 recruitment and activation. Rab29 induces an unexpected tetrameric assemb...
• An unexpected role for a glutamate receptor AI翻译
  作者：Coombs, Ian D.; Farrant, Mark
  作者单位：University of London; University College London
  摘要：Ion channels activated by the neurotransmitter glutamate underlie excitatory signaling between neurons in the brain. In mammals, these ionotropic glutamate receptors (iGluRs) belong to three families formed from GluA, GluN, and GluK subunits, respectively: the alpha-amino-3-hydroxy- 5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate receptors (1). By contrast, receptors of a fourth homologous iGluR family-the delta or GluD receptors-do not respond to glutamate....