作者：Nusinovich, Yevgeniya; Ucko, Isaac Nusinovich
作者：Snieckute, Goda; Ryder, Laura; Vind, Anna Constance; Wu, Zhenzhen; Arendrup, Frederic Schroder; Stoneley, Mark; Chamois, Sebastien; Martinez-Val, Ana; Leleu, Marion; Dreos, Rene; Russell, Alexander; Gay, David Michael; Genzor, Aitana Victoria; Choi, Beatrice So-Yun; Basse, Astrid Linde; Sass, Frederike; Dall, Morten; Dollet, Lucile Chantal Marie; Blasius, Melanie; Willis, Anne E.; Lund, Anders H.; Treebak, Jonas T.; Olsen, Jesper Velgaard; Poulsen, Steen Seier; Pownall, Mary Elizabeth; Jensen, Benjamin Anderschou Holbech; Clemmensen, Christoffer; Gerhart-Hines, Zach; Gatfield, David; Bekker-Jensen, Simon
作者单位：University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Cambridge; University of Lausanne; University of Copenhagen; University of Lausanne; University of Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of York - UK; University of Copenhagen; Novo Nordisk Foundation; University of Copenhagen
摘要：The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAK alpha senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAK alpha activation. Conversely, zebrafish larvae deficient for ZAK alpha are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibi...
作者：Agathokleous, Evgenios; Feng, Zhaozhong; Sicard, Pierre
作者单位：Nanjing University of Information Science & Technology
作者：Engblom, Camilla; Thrane, Kim; Lin, Qirong; Andersson, Alma; Toosi, Hosein; Chen, Xinsong; Steiner, Embla; Lu, Chang; Mantovani, Giulia; Hagemann-Jensen, Michael; Saarenpaa, Sami; Jangard, Mattias; Saez-Rodriguez, Julio; Michaelsson, Jakob; Hartman, Johan; Lagergren, Jens; Mold, Jeff E.; Lundeberg, Joakim; Frisen, Jonas
作者单位：Karolinska Institutet; Royal Institute of Technology; SciLifeLab; SciLifeLab; Royal Institute of Technology; Karolinska Institutet; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Sophiahemmet University; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital
摘要：The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ), a method that maps B cell and T cell receptor sequences in human tissue sections. Spatial VDJ captures lymphocyte clones that match canonical B and T cell distributions and amplifies clonal sequences confirmed by orthogonal methods. We found spatial congruency between...
