-
作者：Coulter, Michael E.; Kemere, Caleb
作者单位：University of California System; University of California San Francisco; Rice University
-
作者：Halewood, Michael; Bagley, Margo A.; Wyss, Markus; Scholz, Amber Hartman
作者单位：Emory University; DSM NV; Leibniz Association; Leibniz Institut fur Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ)
摘要：Benefit sharing should be decoupled from access
-
作者：Pham, Vanha N.; Bruemmer, Kevin J.; Toh, Joel D. W.; Ge, Eva J.; Tenney, Logan; Ward, Carl C.; Dingler, Felix A.; Millington, Christopher L.; Garcia-Prieto, Carlos A.; Pulos-Holmes, Mia C.; Ingolia, Nicholas T.; Pontel, Lucas B.; Esteller, Manel; Patel, Ketan J.; Nomura, Daniel K.; Chang, Christopher J.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Oxford; Institut de Recerca Contra la Leucemia Josep Carreras (IJC); Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Max Planck Society; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; ICREA; University of Barcelona; University of North Carolina; University of North Carolina Charlotte
摘要：One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one-carbon metabolism by inhibiting the biosynthesis of S-adenosylmethionine (SAM), the major methyl donor in cells. FA reacts with privileged, hyperreactive cysteine sites in the proteome, including Cys120 in S-adenosylmethionine synthase isoform ...
-
作者：Tessnow-von Wysocki, Ina; Wang, Mengjiao; Morales-Caselles, Carmen; Woodall, Lucy C.; Syberg, Kristian; Almroth, Bethanie Carney; Fernandez, Marina; Monclus, Laura; Wilson, Scott P.; Warren, Matt; Knoblauch, Doris; Helm, Rebecca R.
作者单位：University of Vienna; Greenpeace; University of Exeter; Universidad de Cadiz; University of Exeter; University of Southampton; Roskilde University; University of Gothenburg; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Institute of Biology & Experimental Medicine; Norwegian University of Science & Technology (NTNU); Georgetown University
-
作者：Wang, Mengjiao; Bauer, Fredric; Syberg, Kristian; Gammage, Tom
作者单位：University of Exeter; Greenpeace; Lund University; Roskilde University; James Cook University
-
作者：Fraser, Barbara
-
作者：O'Toole, Aine; Neher, Richard A.; Ndodo, Nnaemeka; Borges, Vitor; Gannon, Ben; Gomes, Joao Paulo; Groves, Natalie; King, David J.; Maloney, Daniel; Lemey, Philippe; Lewandowski, Kuiama; Loman, Nicholas; Myers, Richard; Omah, Ifeanyi F.; Suchard, Marc A.; Worobey, Michael; Chand, Meera; Ihekweazu, Chikwe; Ulaeto, David; Adetifa, Ifedayo; Rambaut, Andrew
作者单位：University of Edinburgh; University of Basel; Swiss Institute of Bioinformatics; Instituto Nacional de Saude Dr. Ricardo Jorge; UK Health Security Agency (UKHSA); Lusofona University; Universidade de Lisboa; UK Health Security Agency (UKHSA); Defence Science & Technology Laboratory; KU Leuven; University of Birmingham; University of California System; University of California Los Angeles; University of Arizona
摘要：Historically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central Africa. However, in May 2022, human cases of mpox were detected spreading internationally beyond countries with known endemic reservoirs. When the first cases from 2022 were sequenced, they shared 42 nucleotide differences from the closest mpox virus (MPXV) previously sampled. Nearly all these mutations are characteristic of the action of AP...
-
作者：Rodriguez-Montes, Leticia; Ovchinnikova, Svetlana; Yuan, Xuefei; Studer, Tania; Sarropoulos, Ioannis; Anders, Simon; Kaessmann, Henrik; Cardoso-Moreira, Margarida
作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Francis Crick Institute
摘要：Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the development of five organs in five mammals (human, mouse, rat, rabbit, and opossum) and a bird (chicken). We found that sex-biased gene expression varied considerably across organs and species and was ofte...
-
作者：Zhang, Yongqiang; Li, Congcong; Chiew, Francis H. S.; Post, David A.; Zhang, Xuanze; Ma, Ning; Tian, Jing; Kong, Dongdong; Leung, L. Ruby; Yu, Qiang; Shi, Jiancheng; Liu, Changming
作者单位：Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Northwest A&F University - China; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; China University of Geosciences; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Chinese Academy of Sciences; National Space Science Center, CAS
摘要：Global land water underpins livelihoods, socioeconomic development, and ecosystems. It remains unclear how water availability has changed in recent decades. Using an ensemble of observations, we quantified global land water availability over the past two decades. We show that the Southern Hemisphere has dominated the declining trend in global water availability from 2001 to 2020. The significant decrease occurs mainly in South America, southwestern Africa, and northwestern Australia. In the No...
-
作者：Cohen, Jon
