-
作者：Thienel, Manuela; Mueller-Reif, Johannes B.; Zhang, Zhe; Ehreiser, Vincent; Huth, Judith; Shchurovska, Khrystyna; Kilani, Badr; Schweizer, Lisa; Geyer, Philipp E.; Zwiebel, Maximilian; Novotny, Julia; Luesebrink, Enzo; Little, Gemma; Orban, Martin; Nicolai, Leo; El Nemr, Shaza; Titova, Anna; Spannagl, Michael; Kindberg, Jonas; Evans, Alina L.; Mach, Orpheus; Vogel, Matthias; Tiedt, Steffen; Ormanns, Steffen; Kessler, Barbara; Dueck, Anne; Friebe, Andrea; Jorgensen, Peter Godsk; Majzoub-Altweck, Monir; Blutke, Andreas; Polzin, Amin; Stark, Konstantin; Kaab, Stefan; Maier, Doris; Gibbins, Jonathan M.; Limper, Ulrich; Frobert, Ole; Mann, Matthias; Massberg, Steffen; Petzold, Tobias
作者单位：University of Munich; Munich Heart Alliance; German Centre for Cardiovascular Research; Max Planck Society; University of Reading; University of Munich; Norwegian Institute Nature Research; Inland Norway University of Applied Sciences; University of Munich; University of Munich; University of Munich; Technical University of Munich; University of Munich; Helmholtz Association; German Aerospace Centre (DLR); Witten Herdecke University; Orebro University; Aarhus University; Aarhus University; Aarhus University
摘要：Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based pro...
-
作者：Brainard, Jeffrey
-
作者：Campana, Jorge Cortez
作者单位：Pontificia Universidad Catolica de Chile; Universidad de La Serena
-
作者：Chen, Y. Erin; Bousbaine, Djenet; Veinbachs, Alessandra; Atabakhsh, Katayoon; Dimas, Alex; Yu, Victor K.; Zhao, Aishan; Enright, Nora J.; Nagashima, Kazuki; Belkaid, Yasmine; Fischbach, Michael A.
作者单位：Stanford University; Stanford University; Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Chan Zuckerberg Initiative (CZI)
摘要：Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not well defined, limiting our ability to understand anticommensal immunity and harness it therapeutically. We addressed both challenges by engineering the skin bacterium Staphylococcus epidermidis to express tumor antigens anchored to secreted or cel...
-
作者：Brainard, Jeffrey
-
作者：Brainard, Jeffrey
-
作者：Yuan, Xing; Wang, Yumiao; Ji, Peng; Wu, Peili; Sheffield, Justin; Otkin, Jason A.
作者单位：Nanjing University of Information Science & Technology; Nanjing University of Information Science & Technology; Met Office - UK; Hadley Centre; University of Southampton; University of Wisconsin System; University of Wisconsin Madison
摘要：Flash droughts have occurred frequently worldwide, with a rapid onset that challenges drought monitoring and forecasting capabilities. However, there is no consensus on whether flash droughts have become the new normal because slow droughts may also increase. In this study, we show that drought intensification rates have sped up over subseasonal time scales and that there has been a transition toward more flash droughts over 74% of the global regions identified by the Intergovernmental Panel o...
-
作者：Anderson, Deborah J.; Johnston, Daniel S.
作者单位：Boston University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
摘要：Modern contraception ushered in an era of improved family planning, but more than 60 years after approval of the pill, product gaps and unmet needs still exist. Nearly 250 million women worldwide who want to delay or avoid pregnancy do so ineffectively or not at all, and the principal mechanism of male contraception, condoms, has not changed in 100 years. As a result, about half of the pregnancies that occur globally each year are unintended. Increasing contraceptive options and uptake will cu...
-
作者：Herbert, Mary; Choudhary, Meenakshi; Zander-Fox, Deidre
作者单位：Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Monash University; Monash IVF; Monash University
摘要：Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen embryos for inherited genetic disorders of the nuclear and mitochondrial genomes. Progress in identifying causative genetic variants has massively increased the scope of preimplantation genetic testing in preventing genetic disorders. However, beca...
-
作者：Peppe, Daniel J.; Cote, Susanne M.; Deino, Alan L.; Fox, David L.; Kingston, John D.; Kinyanjui, Rahab N.; Lukens, William E.; MacLatchy, Laura M.; Novello, Alice; Stromberg, Caroline A. E.; Driese, Steven G.; Garrett, Nicole D.; Hillis, Kayla R.; Jacobs, Bonnie F.; Jenkins, Kirsten E. H.; Kityo, Robert M.; Lehmann, Thomas; Manthi, Fredrick K.; Mbua, Emma N.; Michel, Lauren A.; Miller, Ellen R.; Mugume, Amon A. T.; Muteti, Samuel N.; Nengo, Isaiah O.; Oginga, Kennedy O.; Phelps, Samuel R.; Polissar, Pratigya; Rossie, James B.; Stevens, Nancy J.; Uno, Kevin T.; McNulty, Kieran P.
作者单位：Baylor University; University of Calgary; Berkeley Geochronolgy Center; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Max Planck Society; Smithsonian Institution; Smithsonian National Museum of Natural History; James Madison University; University of Michigan System; University of Michigan; Institut de Recherche pour le Developpement (IRD); Universite PSL; College de France; INRAE; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Washington; University of Washington Seattle; University of Minnesota System; University of Minnesota Twin Cities; Tennessee Technological University; Southern Methodist University; Makerere University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Wake Forest University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Harvard University; University of California System; University of California Santa Cruz; University System of Ohio; Ohio University; University System of Ohio; Ohio University; Columbia University; Aix-Marseille Universite
摘要：The assembly of Africa's iconic C-4 grassland ecosystems is central to evolutionary interpretations of many mammal lineages, including hominins. C-4 grasses are thought to have become ecologically dominant in Africa only after 10 million years ago (Ma). However, paleobotanical records older than 10 Ma are sparse, limiting assessment of the timing and nature of C-4 biomass expansion. This study uses a multiproxy design to document vegetation structure from nine Early Miocene mammal site complex...
