作者：Lu, Tzu-Chiao; Brbic, Maria; Park, Ye-Jin; Jackson, Tyler; Chen, Jiaye; Kolluru, Sai Saroja; Qi, Yanyan; Katheder, Nadja Sandra; Cai, Xiaoyu Tracy; Lee, Seungjae; Chen, Yen -Chung; Auld, Niccole; Liang, Chung-Yi; Ding, Sophia H.; Welsch, Doug; D'Souza, Samuel; Pisco, Angela Oliveira; Jones, Robert C.; Leskovec, Jure; Lai, Eric C.; Bellen, Hugo J.; Luo, Liqun; Jasper, Heinrich; Quake, Stephen R.; Li, Hongjie
作者单位：Baylor College of Medicine; Baylor College of Medicine; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI); Roche Holding; Roche Holding USA; Genentech; Memorial Sloan Kettering Cancer Center; New York University; Stanford University; Stanford University; Howard Hughes Medical Institute
摘要：Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We characterized 163 distinct cell types and performed an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further developed aging clock models to predict fly age and show that ribosomal gene expre...
作者：Moody, E. R.; Obexer, R.; Nickl, F.; Spiess, R.; Lovelock, S. L.
作者单位：University of Manchester
摘要：Therapeutic oligonucleotides have emerged as a powerful drug modality with the potential to treat a wide range of diseases; however, the rising number of therapies poses a manufacturing challenge. Existing synthetic methods use stepwise extension of sequences immobilized on solid supports and are limited by their scalability and sustainability. We report a biocatalytic approach to efficiently produce oligonucleotides in a single operation where polymerases and endonucleases work in synergy to ...
作者：Boronski, Josef T.; Crumpton, Agamemnon E.; Wales, Lewis L.; Aldridge, Simon
作者单位：University of Oxford
摘要：The complex diberyllocene, CpBeBeCp (Cp, cyclopentadienyl anion), has been the subject of numerous chemical investigations over the past five decades yet has eluded experimental characterization. We report the preparation and isolation of the compound by the reduction of beryllocene (BeCp2) with a dimeric magnesium(I) complex and determination of its structure in the solid state by means of x-ray crystallography. Diberyllocene acts as a reductant in reactions that form beryllium-aluminum and b...
作者：Zielinska-Dabkowska, K. M.; Schernhammer, E. S.; Hanifin, J. P.; Brainard, G. C.
作者单位：Fahrenheit Universities; Gdansk University of Technology; Medical University of Vienna; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; Thomas Jefferson University
摘要：Nocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates that nocturnal light exposure can strain the visual system, disrupt circadian physiology, suppress melatonin secretion, and impair sleep. There is a growing body of work pointing to adverse effects of outdoor lighting on human health, including the risk of chronic diseases, bu...
