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作者：Aymard, Antoine; Delplanque, Emilie; Dalmas, Davy; Scheibert, Julien
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Ecole Centrale de Lyon
摘要：Many devices, including touchscreens and robotic hands, involve frictional contacts. Optimizing these devices requires fine control of the interface's friction law. We lack systematic methods to create dry contact interfaces whose frictional behavior satisfies preset specifications. We propose a generic surface design strategy to prepare dry rough interfaces that have predefined relationships between normal and friction forces. Such metainterfaces circumvent the usual multiscale challenge of t...
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作者：Leslie, Mitch
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作者：Yang, Yujia; Henke, Jan-Wilke; Raja, Arslan S.; Kappert, F. Jasmin; Huang, Guanhao; Arend, Germaine; Qiu, Zheru; Feist, Armin; Wang, Rui Ning; Tusnin, Aleksandr; Tikan, Alexey; Ropers, Claus; Kippenberg, Tobias J.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Gottingen
摘要：The short de Broglie wavelength and strong interaction empower free electrons to probe structures and excitations in materials and biomolecules. Recently, electron-photon interactions have enabled new optical manipulation schemes for electron beams. In this work, we demonstrate the interaction of electrons with nonlinear optical states inside a photonic chip-based microresonator. Optical parametric processes give rise to spatiotemporal pattern formation corresponding to coherent or incoherent ...
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作者：Rostain, Stephen; Dorison, Antoine; de Saulieu, Geoffroy; Pruemers, Heiko; Le Pennec, Jean-Luc; Mejia Mejia, Fernando; Maritza Freire, Ana; Pagan-Jimenez, Jaime R.; Descola, Philippe
作者单位：Centre National de la Recherche Scientifique (CNRS); Ifremer; Universite de Bretagne Occidentale; Centre National de la Recherche Scientifique (CNRS); Pontificia Universidad Catolica del Ecuador; University of Puerto Rico; Universite PSL; College de France
摘要：A dense system of pre-Hispanic urban centers has been found in the Upano Valley of Amazonian Ecuador, in the eastern foothills of the Andes. Fieldwork and light detection and ranging (LIDAR) analysis have revealed an anthropized landscape with clusters of monumental platforms, plazas, and streets following a specific pattern intertwined with extensive agricultural drainages and terraces as well as wide straight roads running over great distances. Archaeological excavations date the occupation ...
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作者：Alvarez, Raymond A.; James, Louisa K.
作者单位：Icahn School of Medicine at Mount Sinai; University of London; Queen Mary University London
摘要：Optimized transfer RNA (tRNA) codon use can speed up antibody generation Antibodies are critical for human health, providing long-lived and exquisitely specific immunity to pathogens. Plasma cells secrete tens of thousands of antibody molecules every second and sustain this output continuously for several decades. Plasmablasts and plasma cells [collectively, antibody-secreting cells (ASCs)] are generated following the activation and differentiation of B cells, which involves complete reprogram...
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作者：Oransky, Ivan; Redman, Barbara
作者单位：New York University; New York University; New York University
摘要：Scientific misconduct is an issue rife with controversy, from its forms and definitions to the policies that guide how allegations are handled. A survey published nearly 15 years ago reported that 2% of researchers said they had fabricated or falsified data in their published work. This is not just an academic issue. Fake data promote ineffective or even dangerous treatments, for example, and thwart the discovery of real solutions for society. In the United States, the Office of Research Integ...
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作者：Sharma, Pankaj; Zhang, Xiaolong; Ly, Kevin; Kim, Ji Hyung; Wan, Qi; Kim, Jessica; Lou, Mumeng; Kain, Lisa; Teyton, Luc; Winau, Florian
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard Medical School; Scripps Research Institute
摘要：Tumors develop strategies to evade immunity by suppressing antigen presentation. In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor immunity and that its hyperglycosylation in tumor dendritic cells (DCs) leads to cancer immune escape. We found that lysosomal pSAP and its single-saposin cognates mediated disintegration of tumor cell-derived apoptotic bodies to facilitate presentation of membrane-associated antigen and T cell activation. In the tumor microenvironment, ...
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作者：Cohen, Jon
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作者：Brainard, Jeffrey
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作者：Cui, Jiyu; Zhang, Zhaoqiang; Yang, Lifeng; Hu, Jianbo; Jin, Anye; Yang, Zhenglu; Zhao, Yue; Meng, Biao; Zhou, Yu; Wang, Jun; Su, Yun; Cui, Xili; Xing, Huabin
作者单位：Zhejiang University; National University of Singapore; Nanjing University; Nanjing Tech University; Nanchang University
摘要：The design of molecular sieves is vital for gas separation, but it suffers from a long-standing issue of slow adsorption kinetics due to the intrinsic contradiction between molecular sieving and diffusion within restricted nanopores. We report a molecular sieve ZU-609 with local sieving channels that feature molecular sieving gates and rapid diffusion channels. The precise cross-sectional cutoff of molecular sieving gates enables the exclusion of propane from propylene. The coexisting large ch...
