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作者：Slesarenko, Viacheslav; Pastewka, Lars
作者单位：University of Freiburg; University of Freiburg
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作者：Brainard, Jeffrey
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作者：Ng, Melissa S. F.; Kwok, Immanuel; Tan, Leonard; Shi, Changming; Cerezo-Wallis, Daniela; Tan, Yingrou; Leong, Keith; Calvo, Gabriel F.; Yang, Katharine; Zhang, Yuning; Jin, Jingsi; Liong, Ka Hang; Wu, Dandan; He, Rui; Liu, Dehua; Teh, Ye Chean; Bleriot, Camille; Caronni, Nicoletta; Liu, Zhaoyuan; Duan, Kaibo; Narang, Vipin; Ballesteros, Ivan; Moalli, Federica; Li, Mengwei; Chen, Jinmiao; Liu, Yao; Liu, Lianxin; Qi, Jingjing; Liu, Yingbin; Jiang, Lingxi; Shen, Baiyong; Cheng, Hui; Cheng, Tao; Angeli, Veronique; Sharma, Ankur; Loh, Yuin-han; Tey, Hong Liang; Chong, Shu Zhen; Iannacone, Matteo; Ostuni, Renato; Hidalgo, Andres; Ginhoux, Florent; Ng, Lai Guan
作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Shanghai Jiao Tong University; Centro Nacional de Investigaciones Cardiovasculares (CNIC); Yale University; Yale University; National Skin Centre; Universidad de Castilla-La Mancha; Universidad de Castilla-La Mancha; National University of Singapore; National University of Singapore; Shanghai Jiao Tong University; Chinese Academy of Sciences; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Queen Elizabeth II Medical Centre; Harry Perkins Institute of Medical Research; University of Western Australia; Curtin University; Curtin University; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Nanyang Technological University; National University of Singapore; National University of Singapore; Vita-Salute San Raffaele University
摘要：Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：de Lima, Renato A. F.; Dauby, Gilles; de Gasper, Andre L.; Fernandez, Eduardo P.; Vibrans, Alexander C.; de Oliveira, Alexandre A.; Prado, Paulo I.; Souza, Vinicius C.; de Siqueira, Marinez F.; ter Steege, Hans
作者单位：Naturalis Biodiversity Center; Universidade de Sao Paulo; CIRAD; Centre National de la Recherche Scientifique (CNRS); INRAE; Universite de Montpellier; Institut de Recherche pour le Developpement (IRD); Universidade Regional de Blumenau (FURB); Jardim Botanico do Rio de Janeiro; Universidade Regional de Blumenau (FURB); Universidade de Sao Paulo; Utrecht University
摘要：Biodiversity is declining globally, yet many biodiversity hotspots still lack comprehensive species conservation assessments. Using multiple International Union for Conservation of Nature (IUCN) Red List criteria to evaluate extinction risks and millions of herbarium and forest inventory records, we present automated conservation assessments for all tree species of the Atlantic Forest biodiversity hotspot, including similar to 1100 heretofore unassessed species. About 65% of all species and 82...
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作者：Hannibal, Mary Ellen
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作者：Giguere, Sophie; Wang, Xuesong; Huber, Sabrina; Xu, Liling; Warner, John; Weldon, Stephanie R.; Hu, Jennifer; Quynh Anh Phan; Tumang, Katie; Prum, Thavaleak; Ma, Duanduan; Kirsch, Kathrin H.; Nair, Usha; Dedon, Peter; Batista, Facundo D.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Singapore-MIT Alliance for Research & Technology Centre (SMART); Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Antibodies are produced at high rates to provide immunoprotection, which puts pressure on the B cell translational machinery. Here, we identified a pattern of codon usage conserved across antibody genes. One feature thereof is the hyperutilization of codons that lack genome-encoded Watson-Crick transfer RNAs (tRNAs), instead relying on the posttranscriptional tRNA modification inosine (I34), which expands the decoding capacity of specific tRNAs through wobbling. Antibody-secreting cells had in...
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作者：Malakoff, David
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作者：Polman, Albert; Garcia de Abajo, F. Javier
作者单位：AMOLF; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); ICREA
