作者：Chakrabarti, Sampurna; Klich, Jasmin D.; Khallaf, Mohammed A.; Hulme, Amy J.; Sanchez-Carranza, Oscar; Baran, Zuzanna M.; Rossi, Alice; Huang, Angela Tzu-Lun; Pohl, Tobias; Fleischer, Raluca; Fuerst, Carina; Hammes, Annette; Begay, Valerie; Hoernberg, Hanna; Finol-Urdaneta, Rocio K.; Poole, Kate; Dottori, Mirella; Lewin, Gary R.
作者单位：Helmholtz Association; Max Delbruck Center for Molecular Medicine; Egyptian Knowledge Bank (EKB); Assiut University; University of Wollongong; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Humboldt University of Berlin; University of New South Wales Sydney; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：Touch perception is enabled by mechanically activated ion channels, the opening of which excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as an ion channel likely gated by mechanical force, necessary for normal touch sensitivity in mice. Touch insensitivity in Elkin1(-/-) mice was caused by a loss of mechanically activated currents (MA currents) in around half of all sensory neurons activated by light touch (low-threshold mechanoreceptors). Reintroduct...
作者：Westermann, Jens; Srikant, Thanvi; Gonzalo, Adrian; Tan, Hui San; Bomblies, Kirsten
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Genome duplication (generating polyploids) is an engine of novelty in eukaryotic evolution and a promising crop improvement tool. Yet newly formed polyploids often have low fertility. Here we report that a severe fertility-compromising defect in pollen tube tip growth arises in new polyploids of Arabidopsis arenosa. Pollen tubes of newly polyploid A. arenosa grow slowly, have aberrant anatomy and disrupted physiology, often burst prematurely, and have altered gene expression. These phenotypes ...
作者：Cohen, Jon
摘要：United States and other countries may soon approve virus-proof pigs
作者：Pawar, Pratik
摘要：A dramatic shortage of the oral vaccine may ease in the years ahead as more companies enter the market
