6694期

最新文章

• The positive impact of conservation action AI翻译
  作者：Langhammer, Penny F.; Bull, Joseph W.; Bicknell, Jake E.; Oakley, Joseph L.; Brown, Mary H.; Bruford, Michael W.; Butchart, Stuart H. M.; Carr, Jamie A.; Church, Don; Cooney, Rosie; Cutajar, Simone; Foden, Wendy; Foster, Matthew N.; Gascon, Claude; Geldmann, Jonas; Genovesi, Piero; Hoffmann, Michael; Howard-McCombe, Jo; Lewis, Tiffany; Macfarlane, Nicholas B. W.; Melvin, Zoe E.; Merizalde, Rossana Stoltz; Morehouse, Meredith G.; Pagad, Shyama; Polidoro, Beth; Sechrest, Wes; Segelbacher, Gernot; Smith, Kevin G.; Steadman, Janna; Strongin, Kyle; Williams, Jake; Woodley, Stephen; Brooks, Thomas M.
  作者单位：Arizona State University; Arizona State University-Tempe; University of Oxford; University of Kent; BirdLife International; University of Cambridge; University of York - UK; University of York - UK; Australian National University; University of Malta; Stellenbosch University; University of Copenhagen; Italian Institute for Environmental Protection & Research (ISPRA); Stellenbosch University; Zoological Society of London; Cardiff University; Arizona State University; Arizona State University-Tempe; Bangor University; Conservation International; University of Auckland; Arizona State University; University of Freiburg; Arizona State University; Arizona State University-Tempe; Imperial College London; CGIAR; World Agroforestry (ICRAF); University of the Philippines System; University of the Philippines Los Banos; University of Tasmania
  摘要：Governments recently adopted new global targets to halt and reverse the loss of biodiversity. It is therefore crucial to understand the outcomes of conservation actions. We conducted a global meta-analysis of 186 studies (including 665 trials) that measured biodiversity over time and compared outcomes under conservation action with a suitable counterfactual of no action. We find that in two-thirds of cases, conservation either improved the state of biodiversity or at least slowed declines. Spe...
• Expansive discovery of chemically diverse structured macrocyclic oligoamides AI翻译
  作者：Salveson, Patrick J.; Moyer, Adam P.; Said, Meerit Y.; Gokce, Gizem; Li, Xinting; Kang, Alex; Nguyen, Hannah; Bera, Asim K.; Levine, Paul M.; Bhardwaj, Gaurav; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Small macrocycles with four or fewer amino acids are among the most potent natural products known, but there is currently no way to systematically generate such compounds. We describe a computational method for identifying ordered macrocycles composed of alpha, beta, gamma, and 17 other amino acid backbone chemistries, which we used to predict 14.9 million closed cycles composed of >42,000 monomer combinations. We chemically synthesized 18 macrocycles predicted to adopt single low-energy state...
• Observation of a Chern insulator in crystalline ABCA-tetralayer graphene with spin-orbit coupling AI翻译
  作者：Sha, Yating; Zheng, Jian; Liu, Kai; Du, Hong; Watanabe, Kenji; Taniguchi, Takashi; Jia, Jinfeng; Shi, Zhiwen; Zhong, Ruidan; Chen, Guorui
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; National Institute for Materials Science; National Institute for Materials Science
  摘要：Degeneracies in multilayer graphene, including spin, valley, and layer degrees of freedom, can be lifted by Coulomb interactions, resulting in rich broken-symmetry states. Here, we report a ferromagnetic state in charge-neutral ABCA-tetralayer graphene driven by proximity-induced spin-orbit coupling from adjacent tungsten diselenide. The ferromagnetic state is identified as a Chern insulator with a Chern number of 4; its maximum Hall resistance reaches 78% quantization at zero magnetic field a...
• US government in hot seat for cow flu outbreak response AI翻译
  作者：Cohen, Jon
• Developing future nanomedicines AI翻译
  作者：Feliu, Neus; Parak, Wolfgang J.
  作者单位：University of Hamburg
• Microbes and vitamin D aid immunotherapy AI翻译
  作者：Franco, Fabien; McCoy, Kathy D.
  作者单位：University of Calgary
• Did bold fish spark Lake Tanganyika's diversity? AI翻译
  作者：Pennisi, Elizabeth
  摘要：A gene mutation tied to exploratory behavior may have jump-started the evolution of hundreds of cichlid species
• Colorado protects brain data AI翻译
  作者：Brainard, Jeffrey
• Oldest ice offers view of Earth before the ice ages AI翻译
  作者：Cutts, Elise
  摘要：Bubbles from ancient warm period contain surprisingly low amounts of carbon dioxide
• Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver AI翻译
  作者：Henschke, Sinika; Nolte, Hendrik; Magoley, Judith; Kleele, Tatjana; Brandt, Claus; Hausen, A. Christine; Wunderlich, Claudia M.; Bauder, Corinna A.; Aschauer, Philipp; Manley, Suliana; Langer, Thomas; Wunderlich, F. Thomas; Bruening, Jens C.
  作者单位：University of Cologne; University of Cologne; University of Cologne; Max Planck Society; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Graz; German Center for Diabetes Research (DZD)
  摘要：Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food perception rapidly induced mitochondrial fragmentation in the liver through protein kinase B/AKT (AKT)-dependent phosphorylation of serine 131 of the mitochondrial fission factor (MFFS131). This response was mediated by activation of hypothalamic pro-opiomelanocor...