作者：Stener-Victorin, Elisabet
作者单位：Karolinska Institutet
摘要：Antimalarial suppresses ovarian androgen synthesis to relieve polycystic ovary syndrome
作者：Wang, Xun; Menezes, Cameron J.; Jia, Yuemeng; Xiao, Yi; Venigalla, Siva Sai Krishna; Cai, Feng; Hsieh, Meng-Hsiung; Gu, Wen; Du, Liming; Sudderth, Jessica; Kim, Dohun; Shelton, Spencer D.; Llamas, Claire B.; Lin, Yu-Hsuan; Zhu, Min; Merchant, Salma; Bezwada, Divya; Kelekar, Sherwin; Zacharias, Lauren G.; Mathews, Thomas P.; Hoxhaj, Gerta; Wynn, R. Max; Tambar, Uttam K.; Deberardinis, Ralph J.; Zhu, Hao; Mishra, Prashant
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron transport chain (ETC)-dysfunctional hepatocytes due to an inability to generate acetyl-CoA from peripheral fatty acids through mitochondrial beta-oxidation. Alternative modes for acetyl-CoA production from pyruvate or acetate are suppressed in the setting of ETC ...
作者：Keller, Michelle; Petrov, Dimitar; Gloger, Andreas; Dietschi, Bastien; Jobin, Kilian; Gradinger, Timon; Martinelli, Adriano; Plais, Louise; Onda, Yuichi; Neri, Dario; Scheuermann, Joerg
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The first drugs discovered using DNA-encoded chemical library (DEL) screens have entered late-stage clinical development. However, DEL technology as a whole still suffers from poor chemical purity resulting in suboptimal performance. In this work, we report a technique to overcome this issue through self-purifying release of the DEL after magnetic bead-based synthesis. Both the first and last building blocks of each assembled library member were linked to the beads by tethers that could be cle...
