6701期

最新文章

• Gene editing flows to the lungs AI翻译
  作者：Bulcaen, Mattijs; Carlon, Marianne S.
  作者单位：KU Leuven
  摘要：The lungs encompass a vast surface for gas exchange-they are the bellows that keep the body oxygenated and its metabolism burning. When problems arise in the lungs, severe diseases follow, such as cystic fibrosis. Development of gene therapies for cystic fibrosis has been challenging, especially because delivery usually involves inhalation. Permanently exposed to the hostile outside environment, the lungs are equipped with defense mechanisms to keep inhaled particles and pathogens out of the l...
• In vivo editing of lung stem cells for durable gene correction in mice AI翻译
  作者：Sun, Yehui; Chatterjee, Sumanta; Lian, Xizhen; Traylor, Zachary; Sattiraju, Sandhya R.; Xiao, Yufen; Dilliard, Sean A.; Sung, Yun-Chieh; Kim, Minjeong; Lee, Sang M.; Moore, Stephen; Wang, Xu; Zhang, Di; Wu, Shiying; Basak, Pratima; Wang, Jialu; Liu, Jing; Mann, Rachel J.; Lepage, David F.; Jiang, Weihong; Abid, Shadaan; Hennig, Mirko; Martinez, Anna; Wustman, Brandon A.; Lockhart, David J.; Jain, Raksha; Conlon, Ronald A.; Drumm, Mitchell L.; Hodges, Craig A.; Siegwart, Daniel J.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University System of Ohio; Case Western Reserve University; University of Texas System; University of Texas Southwestern Medical Center
  摘要：In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. In this work, we demonstrate that optimized lung-targeting lipid nanoparticles (LNPs) enable high levels of genome editing in stem cells, yielding durable responses. Intravenously administered gene-editing LNPs in activatable tdTomato mice achieved >70% lung stem cell editing, sustaining tdTomato expression in >80% of lung epithelial cells for 660 days. Addressing...
• New Alzheimer's drug clears FDA advisory vote despite unknowns AI翻译
  作者：Couzin-Frankel, Jennifer
  摘要：Pivotal trial of Eli Lilly's donanemab leaves questions about how to prescribe it and minimize risks
• Threats posed by water transfer in Iran AI翻译
  作者：Mohammadi, Alireza; Azareh, Ali; Rafiei-Sardooi, Elham; Khanjani, Mohammad Hossein
• An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery AI翻译
  作者：Huang, Qin; Chan, Ken Y.; Wu, Jason; Botticello-Romero, Nuria R.; Zheng, Qingxia; Lou, Shan; Keyes, Casey; Svanbergsson, Alexander; Johnston, Jencilin; Mills, Allan; Lin, Chin-Yen; Brauer, Pamela P.; Clouse, Gabrielle; Pacouret, Simon; Harvey, John W.; Beddow, Thomas; Hurley, Jenna K.; Tobey, Isabelle G.; Powell, Megan; Chen, Albert T.; Barry, Andrew J.; Eid, Fatma-Elzahraa; Chan, Yujia A.; Deverman, Benjamin E.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Egyptian Knowledge Bank (EKB); Al Azhar University
  摘要：Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that binds human transferrin receptor (TfR1), a protein expressed on the blood-brain barrier. BI-hTFR1 was actively transported across human brain endothelial cells and, relative to AAV9, provided 40 to 50 times greater reporter expression in the CNS of human TFRC knockin mice. ...
• Scientists in exile AI翻译
  作者：Machlis, Gary E.; Carrero-Martinez, Franklin A.
  作者单位：Clemson University; National Academies of Sciences, Engineering & Medicine
  摘要：Since 2001, the United Nations has designated 20 June as World Refugee Day. It seeks to raise awareness of refugees-currently estimated to be more than 114 million persons internally displaced, exiled, or on the move-and the often-harsh conditions they confront around the world. Among them are scientists, giving the scientific community a special responsibility to protect and support these colleagues. It is not just scientists and their families whose lives are disrupted, but science as an ent...
• Signs of science AI翻译
  作者：Selibas, Dimitri
  摘要：CyberTracker, software developed in collaboration with Indigenous trackers, is enabling almost anyone to collect complex biodiversity data
• Cloud-brightening study halted AI翻译
  作者：Warren, Matthew
• Biogenic-to-lithogenic handoff of particulate Zn affects the Zn cycle in the Southern Ocean AI翻译
  作者：Duan, J.; Cloete, R.; Loock, J. C.; Lanzirotti, A.; Newville, M.; Martinez-Garcia, A.; Sigman, D. M.; Lam, P. J.; Roychoudhury, A. N.; Myneni, S. C. B.
  作者单位：Princeton University; Stellenbosch University; University of Chicago; Max Planck Society; University of California System; University of California Santa Cruz
  摘要：Zinc (Zn) is vital to marine organisms. Its active uptake by phytoplankton results in a substantial depletion of dissolved Zn, and Zn bound to particulate organic matter replenishes dissolved Zn in the ocean through remineralization. However, we found that particulate Zn changes from Zn bound to phosphoryls in cells to recalcitrant inorganic pools that include biogenic silica, clays, and iron, manganese, and aluminum oxides in the Southern Ocean water column. The abundances of inorganic pools ...
• Rethinking quantum orthodoxy AI翻译
  作者：Halpern, Paul
  作者单位：Saint Joseph's University
  摘要：A physicist makes the case for a deterministic alternative to quantum mechanics