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作者：Karimuzzaman, Md
作者单位：Drexel University
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作者：Klages, J. P.; Hillenbrand, C. D.; Bohaty, S. M.; Salzmann, U.; Bickert, T.; Lohmann, G.; Knahl, H. S.; Gierz, P.; Niu, L.; Titschack, J.; Kuhn, G.; Frederichs, T.; Mueller, J.; Bauersachs, T.; Larter, R. D.; Hochmuth, K.; Ehrmann, W.; Nehrke, G.; Rodriguez-Tovar, F. J.; Schmiedl, G.; Spezzaferri, S.; Laeufer, A.; Lisker, F.; van de Flierdt, T.; Eisenhauer, A.; Uenzelmann-Neben, G.; Esper, O.; Smith, J. A.; Paelike, H.; Spiegel, C.; Dziadek, R.; Ronge, T. A.; Freudenthal, T.; Gohl, K.
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Ruprecht Karls University Heidelberg; Northumbria University; University of Bremen; University of Bremen; University of Bremen; RWTH Aachen University; University of Tasmania; Leipzig University; University of Granada; University of Hamburg; University of Fribourg; Imperial College London; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Texas A&M University System; Texas A&M University College Station
摘要：One of Earth's most fundamental climate shifts, the greenhouse-icehouse transition 34 million years ago, initiated Antarctic ice sheet buildup, influencing global climate until today. However, the extent of the ice sheet during the Early Oligocene Glacial Maximum (similar to 33.7 to 33.2 million years ago) that immediately followed this transition-a critical knowledge gap for assessing feedbacks between permanently glaciated areas and early Cenozoic global climate reorganization-is uncertain. ...
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作者：An, Linna; Said, Meerit; Tran, Long; Majumder, Sagardip; Goreshnik, Inna; Lee, Gyu Rie; Juergens, David; Dauparas, Justas; Anishchenko, Ivan; Coventry, Brian; Bera, Asim K.; Kang, Alex; Levine, Paul M.; Alvarez, Valentina; Pillai, Arvind; Norn, Christoffer; Feldman, David; Zorine, Dmitri; Hicks, Derrick R.; Li, Xinting; Sanchez, Mariana Garcia; Vafeados, Dionne K.; Salveson, Patrick J.; Vorobieva, Anastassia A.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Brussel
摘要：We describe an approach for designing high-affinity small molecule-binding proteins poised for downstream sensing. We use deep learning-generated pseudocycles with repeating structural units surrounding central binding pockets with widely varying shapes that depend on the geometry and number of the repeat units. We dock small molecules of interest into the most shape complementary of these pseudocycles, design the interaction surfaces for high binding affinity, and experimentally screen to ide...
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作者：Janssen, Marvin; Frederichs, Thomas; Olaru, Marian; Lork, Enno; Hupf, Emanuel; Beckmann, Jens
作者单位：University of Bremen; University of Bremen
摘要：Nitrenes are a highly reactive, yet fundamental, compound class. They possess a monovalent nitrogen atom and usually a short life span, typically in the nanosecond range. Here, we report on the synthesis of a stable nitrene by photolysis of the arylazide M(S)FluindN(3) (1), which gave rise to the quantitative formation of the arylnitrene M(S)FluindN (2) (M(S)Fluind is dispiro[fluorene-9,3 '-(1 ',1 ',7 ',7 '-tetramethyl-s-hydrindacen-4 '-yl)-5 ',9 ''-fluorene]) that remains unchanged for at lea...
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作者：Koike, Taichi; Yu, Jhen-Kuei; Hansmann, Max M.
作者单位：Dortmund University of Technology
摘要：Precise modification of a chemical site in a molecule at the single-atom level is one of the most elegant yet difficult transformations in chemistry. A reagent specifically designed for chemoselective introduction of monoatomic carbon is a particularly formidable challenge. Here, we report a straightforward, azide-free synthesis of a crystalline and isolable diazophosphorus ylide, Ph3PCN2, a stable compound with a carbon atom bonded to two chemically labile groups, triphenylphosphine (PPh3) an...
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作者：Voosen, Paul
摘要：NASA investigates flaws in radiation-hardened electronics NASA investigates flaws in radiation-hardened electronics
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作者：Berhanu, Samuel; Majumder, Sagardip; Muentener, Thomas; Whitehouse, James; Berner, Carolin; Bera, Asim K.; Kang, Alex; Liang, Binyong; Khan, Nasir; Sankaran, Banumathi; Tamm, Lukas K.; Brockwell, David J.; Hiller, Sebastian; Radford, Sheena E.; Baker, David; Vorobieva, Anastassia A.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Basel; University of Leeds; Vrije Universiteit Brussel; Flanders Institute for Biotechnology (VIB); University of Virginia; University of Virginia; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：Transmembrane beta-barrels have considerable potential for a broad range of sensing applications. Current engineering approaches for nanopore sensors are limited to naturally occurring channels, which provide suboptimal starting points. By contrast, de novo protein design can in principle create an unlimited number of new nanopores with any desired properties. Here we describe a general approach to designing transmembrane beta-barrel pores with different diameters and pore geometries. Nuclear ...
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作者：Dhorda, Mehul; Kaneko, Akira; Komatsu, Ryuichi; Achyut, K. C.; Mshamu, Salum; Gesase, Samwel; Kapologwe, Ntuli; Assefa, Ashenafi; Opigo, Jimmy; Adoke, Yeka; Ebong, Chris; Karema, Corine; Uwimana, Aline; Mangara, Jean-Louis Ndikumana; Amaratunga, Chanaki; Peto, Thomas J.; Tripura, Rupam; Callery, James J.; Adhikari, Bipin; Mukaka, Mavuto; Cheah, Phaik Yeong; Mutesa, Leon; Day, Nicholas P. J.; Barnes, Karen I.; Dondorp, Arjen; Rosenthal, Philip J.; White, Nicholas J.; von Seidlein, Lorenz
作者单位：Mahidol Oxford Tropical Medicine Research Unit (MORU); Mahidol University; University of Oxford; Karolinska Institutet; Nagasaki University; National Institute of Medical Research; University of North Carolina; University of North Carolina Chapel Hill; Ministry of Health - Uganda; Rwanda Biomedical Center; University of Rwanda; University of Cape Town; University of California System; University of California San Francisco
摘要：Artemisinin derivatives are the cornerstone of current antimalarial treatment, both for severe malaria (injectable artesunate) and uncomplicated malaria [artemisinin combination therapy (ACT)]. Although a large but poorly defined proportion of malaria infections remains undiagnosed, about 249 million uncomplicated cases were estimated worldwide in 2022, of which roughly 65% were treated with ACTs. Of these cases, 233 million (94%) occurred in Africa ( 1 ), where >70% of uncomplicated falciparu...
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作者：Takenouchi, Osamu; Sakakibara, Yogo; Kitajima, Tomoya S.
作者单位：RIKEN
摘要：Meiotic errors of relatively small chromosomes in oocytes result in egg aneuploidies that cause miscarriages and congenital diseases. Unlike somatic cells, which preferentially mis-segregate larger chromosomes, aged oocytes preferentially mis-segregate smaller chromosomes through unclear processes. Here, we provide a comprehensive three-dimensional chromosome identifying-and-tracking dataset throughout meiosis I in live mouse oocytes. This analysis reveals a prometaphase pathway that actively ...
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作者：Thorp, H. Holden
