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作者：Savitsky, Zack
摘要：Researchers create fresh tools to attack famed Riemann hypothesis, math's biggest unsolved problem
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作者：Dhand, Abhishek P.; Davidson, Matthew D.; Zlotnick, Hannah M.; Kolibaba, Thomas J.; Killgore, Jason P.; Burdick, Jason A.
作者单位：University of Pennsylvania; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA
摘要：Incorporation of polymer chain entanglements within a single network can synergistically improve stiffness and toughness, yet attaining such dense entanglements through vat photopolymerization additive manufacturing [e.g., digital light processing (DLP)] remains elusive. We report a facile strategy that combines light and dark polymerization to allow constituent polymer chains to densely entangle as they form within printed structures. This generalizable approach reaches high monomer conversio...
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作者：Kupferschmidt, Kai
摘要：Twice-yearly lenacapavir injections provide 100% protection in study in African women
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作者：Peters, Jonathan J. P.; Reed, Bryan W.; Jimbo, Yu; Noguchi, Kanako; Mueller, Karin H.; Porter, Alexandra; Masiel, Daniel J.; Jones, Lewys
作者单位：Trinity College Dublin; Trinity College Dublin; Jeol Ltd; Imperial College London
摘要：An ever-present limitation of transmission electron microscopy is the damage caused by high-energy electrons interacting with any sample. By reconsidering the fundamentals of imaging, we demonstrate an event-responsive approach to electron microscopy that delivers more information about the sample for a given beam current. Measuring the time to achieve an electron count threshold rather than waiting a predefined constant time improves the information obtained per electron. The microscope was m...
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作者：Enserink, Martin
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作者：Satterlee, James W.; Alonso, David; Gramazio, Pietro; Jenike, Katharine M.; He, Jia; Arrones, Andrea; Villanueva, Gloria; Plazas, Mariola; Ramakrishnan, Srividya; Benoit, Matthias; Gentile, Iacopo; Hendelman, Anat; Shohat, Hagai; Fitzgerald, Blaine; Robitaille, Gina M.; Green, Yumi; Swartwood, Kerry; Passalacqua, Michael J.; Gagnon, Edeline; Hilgenhof, Rebecca; Huggins, Trevis D.; Eizenga, Georgia C.; Gur, Amit; Rutten, Twan; Stein, Nils; Yao, Shengrui; Poncet, Adrien; Bellot, Clement; Frary, Amy; Knapp, Sandra; Bendahmane, Mohammed; Saerkinen, Tiina; Gillis, Jesse; Van Eck, Joyce; Schatz, Michael C.; Eshed, Yuval; Prohens, Jaime; Vilanova, Santiago; Lippman, Zachary B.
作者单位：Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; Howard Hughes Medical Institute; Universitat Politecnica de Valencia; Johns Hopkins University; Johns Hopkins University; INRAE; Cold Spring Harbor Laboratory; Cornell University; Boyce Thompson Institute for Plant Research; University of Guelph; United States Department of Agriculture (USDA); Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Martin Luther University Halle Wittenberg; New Mexico State University; New Mexico State University; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Mount Holyoke College; Natural History Museum London; University of Toronto; University of Toronto; Cornell University; Weizmann Institute of Science
摘要：An enduring question in evolutionary biology concerns the degree to which episodes of convergent trait evolution depend on the same genetic programs, particularly over long timescales. In this work, we genetically dissected repeated origins and losses of prickles-sharp epidermal projections-that convergently evolved in numerous plant lineages. Mutations in a cytokinin hormone biosynthetic gene caused at least 16 independent losses of prickles in eggplants and wild relatives in the genus Solanu...
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作者：Yuan, Zuanning; Georgescu, Roxana; Yao, Nina Y.; Yurieva, Olga; O'Donnell, Michael E.; Li, Huilin
作者单位：Van Andel Institute; Rockefeller University; Howard Hughes Medical Institute
摘要：The proliferating cell nuclear antigen (PCNA) clamp encircles DNA to hold DNA polymerases (Pols) to DNA for processivity. The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific to the leading-strand Pol (Pol epsilon). We reveal here the underlying mechanism of Ctf18-RFC specificity to Pol epsilon using cryo-electron microscopy and biochemical studies. We found that both Ctf18-RFC and Pol epsilon contain specific structural features that direct PCNA loading onto DNA. Unlik...
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作者：Qian, Suxin; Takeuchi, Ichiro
作者单位：Xi'an Jiaotong University; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
摘要：Emerging solid-state cooling technologies may help reduce overall carbon emissions
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作者：Rochmyaningsih, Dyna
摘要：European Union faces calls to delay commodity import rules aimed at protecting forests
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作者：Zhu, Yangyang; Meerschaert, Kimberly A.; Galvan-Pena, Silvia; Bin, Na-Ryum; Yang, Daping; Basu, Himanish; Kawamoto, Ryo; Shalaby, Amre; Liberles, Stephen D.; Mathis, Diane; Benoist, Christophe; Chiu, Isaac M.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要：Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly defined neuron subsets and of immunocyte lineages remains unclear. We used a chemogenetic approach to activate eight distinct neuronal subsets, assessing effects by deep immunophenotyping, microbiome profiling, and immunocyte transcriptomics in intestinal organs. Distinct immune perturbations followed neuronal activation: Nitrergic neurons reg...
