作者：Darragh, Jen; Narlock, Mikala R.; Burns, Halle; Cerda, Peter A.; Cowles, Wind; Delserone, Leslie; Erickson, Seth; Herndon, Joel; Imker, Heidi; Johnston, Lisa R.; Lake, Sherry; Lenard, Michael; Mohr, Alicia Hofelich; Moore, Jennifer; Petters, Jonathan; Pullen, Brandie; Taylor, Shawna; Wham, Briana
作者单位：Duke University; University of Minnesota System; University of Minnesota Twin Cities; Princeton University; University of Michigan System; University of Michigan; University of Nebraska System; University of Nebraska Lincoln; University of California System; University of California Santa Barbara; University of Illinois System; University of Illinois Urbana-Champaign; University of Wisconsin System; University of Wisconsin Madison; University of Virginia; University of Minnesota System; University of Minnesota Twin Cities; Washington University (WUSTL); Virginia Polytechnic Institute & State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
作者：Pessoa Rodrigues, Cecilia; Collins, Joseph M.; Yang, Song; Martinez, Catherine; Kim, Ji Wook; Lama, Chhiring; Nam, Anna S.; Alt, Clemens; Lin, Charles; Zon, Leonard I.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Cornell University; Weill Cornell Medicine; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an eat-me signal induced by reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as a crucial don't eat-me signal on blood stem cells. A chemical screen revealed inducers of surface Calr that promoted HSC proliferation without triggering ROS or macrophage clearance. Whole-genome CRISPR-Cas9 screening showed that Toll-like receptor 3 (Tlr3) signa...
作者：Bartolotta, Sabrina
作者单位：Catholic University of the Sacred Heart
