作者：Enserink, Martin; Malakoff, David; Kupferschmidt, Kai; Stokstad, Erik
作者：Jones, Dakota L.; Morley, Michael P.; Li, Xinyuan; Ying, Yun; Zhao, Gan; Schaefer, Sarah E.; Rodriguez, Luis R.; Cardenas-Diaz, Fabian L.; Li, Shanru; Zhou, Su; Chembazhi, Ullas V.; Kim, Mijeong; Shen, Chen; Nottingham, Ana; Lin, Susan M.; Cantu, Edward; Diamond, Joshua M.; Basil, Maria C.; Vaughan, Andrew E.; Morrisey, Edward E.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this stem cell collision generates an injury-induced tissue niche containing keratin 5+ epithelial cells and plastic Pdgfra+ mesenchymal cells. Single-cell analysis revealed that the injury-induced niche is governed by mesenchymal proliferation and Notch signaling, which suppressed Wnt/Fgf signaling in the injured niche. Conversely, loss of Notch signal...
