2024

最新文章

• Megaproject will chart human immune diversity AI翻译
  作者：Leslie, Mitch
• Changing outdated expectations AI翻译
  作者：Singh, Garima
• Supramolecular assembly of blue and green halide perovskites with near-unity photoluminescence AI翻译
  作者：Zhu, Cheng; Jin, Jianbo; Wang, Zhen; Xu, Zhenpeng; Folgueras, Maria C.; Jiang, Yuxin; Uzundal, Can B.; Le, Han K. D.; Wang, Feng; Zheng, Xiaoyu (Rayne); Yang, Peidong
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The metal-halide ionic octahedron is the optoelectronic unit for halide perovskites, and a crown ether-assisted supramolecular assembly approach can pack various ionic octahedra into tunable symmetries. In this work, we demonstrate near-unity photoluminescence quantum yield (PLQY) blue and green emission with the supramolecular assembly of hafnium (Hf) and zirconium (Zr) halide octahedral clusters. (18C6@K)(2)HfBr6 powders showed blue emission with a near-unity PLQY (96.2%), and green emission...
• Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors AI翻译
  作者：Lo, Bernard C.; Kryczek, Ilona; Yu, Jiali; Vatan, Linda; Caruso, Roberta; Matsumoto, Masanori; Sato, Yosuke; Shaw, Michael H.; Inohara, Naohiro; Xie, Yuying; Lei, Yu Leo; Zou, Weiping; Nunez, Gabriel
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Takeda Pharmaceutical Company Ltd; Takeda Pharmaceuticals International, Inc.; Michigan State University; University of Michigan System; University of Michigan
  摘要：Immune checkpoint inhibitors can stimulate antitumor immunity but can also induce toxicities termed immune-related adverse events (irAEs). Colitis is a common and severe irAE that can lead to treatment discontinuation. Mechanistic understanding of gut irAEs has been hampered because robust colitis is not observed in laboratory mice treated with checkpoint inhibitors. We report here that this limitation can be overcome by using mice harboring the microbiota of wild-caught mice, which develop ov...
• First fruits of Long Covid trials AI翻译
  作者：Brainard, Jeffrey
• Creating the plumber's nightmare AI翻译
  作者：Nedoma, Alisyn J.
  作者单位：University of Sheffield
  摘要：Chemically modifying polymer ends enables tailoring of nanostructured materials
• Peru moves to crack down on fraud in research publishing AI翻译
  作者：Orfila, Maria de los Angeles
• What's coming up in 2024 AI翻译
  作者：Brainard, Jeffrey
• Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors AI翻译
  作者：Maharana, Jagannath; Sano, Fumiya K.; Sarma, Parishmita; Yadav, Manish K.; Duan, Longhan; Stepniewski, Tomasz M.; Chaturvedi, Madhu; Ranjan, Ashutosh; Singh, Vinay; Saha, Sayantan; Mahajan, Gargi; Chami, Mohamed; Shihoya, Wataru; Selent, Jana; Chung, Ka Young; Banerjee, Ramanuj; Nureki, Osamu; Shukla, Arun K.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; University of Tokyo; Sungkyunkwan University (SKKU); Hospital del Mar Research Institute; Hospital del Mar; Pompeu Fabra University; University of Basel
  摘要：beta-arrestins (beta arrs) are multifunctional proteins involved in signaling and regulation of seven transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist-induced receptor activation and phosphorylation. Here, we present seven cryo-electron microscopy structures of beta arrs either in the basal state, activated by the muscarinic receptor subtype 2 (M2R) through its third intracellular loop, or activated by the beta arr-biased decoy D6 receptor (D6R). Combined w...
• El Nino may extend record heat AI翻译
  作者：Brainard, Jeffrey