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作者：Zhang, Han-Yue; Tang, Yuan-Yuan; Gu, Zhu-Xiao; Wang, Peng; Chen, Xiao-Gang; Lv, Hui-Peng; Li, Peng-Fei; Jiang, Qing; Gu, Ning; Ren, Shenqiang; Xiong, Ren-Gen
作者单位：Southeast University - China; Nanchang University; Nanjing University; Nanjing University; University System of Maryland; University of Maryland College Park
摘要：Transient implantable piezoelectric materials are desirable for biosensing, drug delivery, tissue regeneration, and antimicrobial and tumor therapy. For use in the human body, they must show flexibility, biocompatibility, and biodegradability. These requirements are challenging for conventional inorganic piezoelectric oxides and piezoelectric polymers. We discovered high piezoelectricity in a molecular crystal HOCH2(CF2)(3)CH2OH [2,2,3,3,4,4-hexafluoropentane-1,5-diol (HFPD)] with a large piez...
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作者：Handley, Margaret A.
作者单位：University of California System; University of California San Francisco
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作者：Meitinger, Franz; Belal, Hazrat; Davis, Robert L.; Martinez, Mallory B.; Shiau, Andrew K.; Oegema, Karen; Desai, Arshad
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Ludwig Institute for Cancer Research; Okinawa Institute of Science & Technology Graduate University; Ludwig Institute for Cancer Research
摘要：Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic cells prone to chromosome missegregation and genomic instability. We show here that mitotic extension leads to the formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 protein complexes that are transmitted to, and stably retained by, daughter cells. Complexes assembled through a Polo-like kinase 1-dependent mechanism during extended mitosis and elicited a p53 respons...
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作者：Vogel, Felix; Hammer, Samuel
作者单位：Environment & Climate Change Canada; Ruprecht Karls University Heidelberg
摘要：Ingeborg Levin, groundbreaking physicist who helped quantify the carbon cycle and greenhouse gas emissions, died on 10 February. She was 70. Ingeborg established high-quality long-term measurements to identify the radiocarbon present in carbon dioxide and inform estimates of carbon fluxes. In the late 1970s, climate change and greenhouse gases were far from a mainstream interest, but Ingeborg immediately recognized their importance and the crucial role science would play in informing policy. S...
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作者：Korte, Andrea
摘要：Morton Ann Gernsbacher and Juan S. Ramirez Lugo reelected to AAAS Board of Directors
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作者：Tanentzap, Andrew J.; Fonvielle, Jeremy A.
作者单位：Trent University; University of Cambridge; University of Cambridge
摘要：Dissolved organic matter may offer a way to track and restore the health of fresh waters Freshwater ecosystems, such as lakes and rivers, have been deteriorating in many places worldwide (1). Growing research suggests that many aspects of freshwater health-that is, the maintenance of chemical, physical, and biological integrity-may depend on the composition of dissolved organic matter (DOM) (2). DOM consists of thousands of distinct organic compounds that mainly originate from different plant ...
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作者：Lin, Kang; Eckart, Sebastian; Liang, Hao; Hartung, Alexander; Jacob, Sina; Ji, Qinying; Schmidt, Lothar Ph. H.; Schoeffler, Markus S.; Jahnke, Till; Kunitski, Maksim; Doerner, Reinhard
作者单位：Zhejiang University; Goethe University Frankfurt; Max Planck Society; Shanghai Jiao Tong University; Max Planck Society
摘要：Similar to the optical diffraction of light passing through a material grating, the Kapitza-Dirac effect occurs when an electron is diffracted by a standing light wave. In its original description, the effect is time independent. Here, we extended the Kapitza-Dirac effect to the time domain. By tracking the spatiotemporal evolution of a pulsed electron wave packet diffracted by a 60-femtosecond (where one femtosecond = 10(-15) seconds) standing wave pulse in a pump-probe scheme, we observed ti...
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作者：Singh, Kashish; Lau, Clinton K.; Manigrasso, Giulia; Gama, Jose B.; Gassmann, Reto; Carter, Andrew P.
作者单位：MRC Laboratory Molecular Biology; Universidade do Porto; i3S - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto; University of Oxford
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作者：Tan, Bin; Zhang, Xiaoming; Ansari, Ahmadullah; Jadhav, Prakash; Tan, Haozhou; Li, Kan; Chopra, Ashima; Ford, Alexandra; Chi, Xiang; Ruiz, Francesc Xavier; Arnold, Eddy; Deng, Xufang; Wang, Jun
作者单位：Rutgers University System; Rutgers University New Brunswick; Oklahoma State University System; Oklahoma State University - Stillwater; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Oklahoma State University System; Oklahoma State University - Stillwater; Oklahoma State University System; Oklahoma State University - Stillwater
摘要：The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging drug target. We designed and synthesized 85 noncovalent PLpro inhibitors that bind to a recently discovered ubiquitin binding site and the known BL2 groove pocket near the S4 subsite. Leads inhibited PLpro with the inhibitory constant K-i values from 13.2 to 88.2 nanomolar. The co-crystal structures of PLpro with eight ...
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作者：Brainard, Jeffrey
