-
作者：Zaleski, Andrew
-
作者：Shanker, Varun R.; Bruun, Theodora U. J.; Hie, Brian L.; Kim, Peter S.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University; Stanford University
摘要：Large language models trained on sequence information alone can learn high-level principles of protein design. However, beyond sequence, the three-dimensional structures of proteins determine their specific function, activity, and evolvability. Here, we show that a general protein language model augmented with protein structure backbone coordinates can guide evolution for diverse proteins without the need to model individual functional tasks. We also demonstrate that ESM-IF1, which was only tr...
-
作者：Mervis, Jeffrey
-
作者：Venkatraman, Vijaysree
-
作者：Higgs, Douglas; Kassouf, Mira
作者单位：University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford
-
作者：Calo, Ryan; Starbird, Kate
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
-
作者：Laughlin, Daniel C.; McGill, Brian J.
作者单位：University of Wyoming; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
摘要：Tree species appear to prefer distinct climatic conditions, but the true nature of these preferences is obscured by species interactions and dispersal, which limit species' ranges. We quantified realized and potential thermal niches of 188 North American tree species to conduct a continental-scale test of the architecture of niches. We found strong and consistent evidence that species occurring at thermal extremes occupy less than three-quarters of their potential niches, and species' potentia...
-
作者：Birkholz, Erica A.; Morgan, Chase J.; Laughlin, Thomas G.; Lau, Rebecca K.; Prichard, Amy; Rangarajan, Sahana; Meza, Gabrielle N.; Lee, Jina; Armbruster, Emily; Suslov, Sergey; Pogliano, Kit; Meyer, Justin R.; Villa, Elizabeth; Corbett, Kevin D.; Pogliano, Joe
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Howard Hughes Medical Institute; University of California System; University of California San Diego
摘要：Introns containing homing endonucleases are widespread in nature and have long been assumed to be selfish elements that provide no benefit to the host organism. These genetic elements are common in viruses, but whether they confer a selective advantage is unclear. In this work, we studied intron-encoded homing endonuclease gp210 in bacteriophage Phi PA3 and found that it contributes to viral competition by interfering with the replication of a coinfecting phage, Phi KZ. We show that gp210 targ...
-
作者：Yasuda, Kenji; Zalys-Geller, Evan; Wang, Xirui; Bennett, Daniel; Cheema, Suraj S.; Watanabe, Kenji; Taniguchi, Takashi; Kaxiras, Efthimios; Jarillo-Herrero, Pablo; Ashoori, Raymond
作者单位：Massachusetts Institute of Technology (MIT); Cornell University; Harvard University; Massachusetts Institute of Technology (MIT); National Institute for Materials Science; National Institute for Materials Science; Harvard University
摘要：The persistence of voltage-switchable collective electronic phenomena down to the atomic scale has extensive implications for area- and energy-efficient electronics, especially in emerging nonvolatile memory technology. We investigate the performance of a ferroelectric field-effect transistor (FeFET) based on sliding ferroelectricity in bilayer boron nitride at room temperature. Sliding ferroelectricity represents a different form of atomically thin two-dimensional (2D) ferroelectrics, charact...
-
作者：Albino, Rayane da Cruz; Brimble, Mark Allen; Zdenek, Christina; Vandenbroeck, Katrien; Masud, Sarah; Zhang, Xuan; Cosentino, Mel; Gupta, Ankita; Abdul-Ghani, Rashad; Gerarduzzi, Casimiro; Jackson, Pamela; Oomen, Rebekah; Servais, Bram; Manjunatha, Akshatha; Bulthuis, Nick; Romero-Molina, Carmen; Teng, Dequn; Kosanic, Aleksandra; Dutra, Daniela de Angeli; Alekkou, Demos; Venturini, Andressa M.; Virguez, Edgar; Obasa, Adetayo Emmanuel
作者单位：Universidade Federal do Rio de Janeiro; St Jude Children's Research Hospital; University of Queensland; KU Leuven; Indraprastha Institute of Information Technology Delhi; Shantou University; Aarhus University; Banaras Hindu University (BHU); Universite de Montreal; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of New Brunswick; University of Melbourne; University of Pennsylvania; Columbia University; Icahn School of Medicine at Mount Sinai; University of Cambridge; Liverpool John Moores University; Stanford University; University of Nicosia; Carnegie Institution for Science; Stellenbosch University
