6732期

最新文章

• A single gene orchestrates androgen variation underlying male mating morphs in ruffs AI翻译
  作者：Loveland, Jasmine L.; Zemella, Alex; Jovanovic, Vladimir M.; Moeller, Gabriele; Sager, Christoph P.; Bastos, Barbara; Dyar, Kenneth A.; Fusani, Leonida; Gahr, Manfred; Giraldo-Deck, Lina M.; Goymann, Wolfgang; Lank, David B.; Tokarz, Janina; Nowick, Katja; Kuepper, Clemens
  作者单位：University of Vienna; Free University of Berlin; Free University of Berlin; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Universidade do Porto; University of Veterinary Medicine Vienna; University of Munich; Simon Fraser University
  摘要：Androgens are pleiotropic and play pivotal roles in the formation and variation of sexual phenotypes. We show that differences in circulating androgens between the three male mating morphs in ruff sandpipers are linked to 17-beta hydroxysteroid dehydrogenase 2 (HSD17B2), encoded by a gene within the supergene that determines the morphs. Low-testosterone males had higher HSD17B2 expression in blood than high-testosterone males, as well as in brain areas related to social behaviors and testoster...
• Variable impacts of land-based climate mitigation on habitat area for vertebrate diversity AI翻译
  作者：Smith, Jeffrey R.; Beaury, Evelyn M.; Cook-Patton, Susan C.; Levine, Jonathan M.
  作者单位：Princeton University; Princeton University; New York Botanical Garden; Nature Conservancy
  摘要：Pathways to achieving net zero carbon emissions commonly involve deploying reforestation, afforestation, and bioenergy crops across millions of hectares of land. It is often assumed that by helping to mitigate climate change, these strategies indirectly benefit biodiversity. Here, we modeled the climate and habitat requirements of 14,234 vertebrate species and show that the impact of these strategies on species' habitat area tends not to arise through climate mitigation, but rather through hab...
• 'Cataclysmic:' Experts decry US departure from WHO AI翻译
  作者：Vogel, Gretchen
• Canadian science girds for shift AI翻译
  作者：Owens, Brian
• Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension AI翻译
  作者：Harvey, Lloyd D.; Alotaibi, Mona; Tai, Yi-Yin; Tang, Ying; Kim, Hee-Jung J.; Kelly, Neil J.; Sun, Wei; Woodcock, Chen-Shan C.; Arshad, Sanya; Culley, Miranda K.; El Khoury, Wadih; Xie, Rong; Al Aaraj, Yassmin; Zhao, Jingsi; Hafeez, Neha; Rao, Rashmi J.; Jiang, Siyi; Negi, Vinny; Kirillova, Anna; Perk, Dror; Watson, Annie M.; St Croix, Claudette M.; Stolz, Donna B.; Lee, Ji Young; Cheng, Mary Hongying; Zhang, Manling; Detmer, Samuel; Guzman, Edward; Manan, Rajith S.; Saggar, Rajan; Haley, Kathleen J.; Waxman, Aaron B.; Okawa, Satoshi; Schwantes-An, Tae-Hwi; Pauciulo, Michael W.; Wang, Bing; Webb, Amy; Chauvet, Caroline; Anderson, Daniel G.; Nichols, William C.; Desai, Ankit A.; Lafyatis, Robert; Nouraie, S. Mehdi; Wu, Haodi; McDonald, Jeffrey G.; Cheng, Susan; Bahar, Ivet; Bertero, Thomas; Benza, Raymond L.; Jain, Mohit; Chan, Stephen Y.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Pittsburgh Healthcare System; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis; University System of Ohio; Cincinnati Children's Hospital Medical Center; University of Cincinnati; University System of Ohio; Ohio State University; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Cedars Sinai Medical Center; Icahn School of Medicine at Mount Sinai
  摘要：Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (NCOA7) deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes. This oxysterol signature overlapped with a plasma metabolite signat...
• A path to US Tribal energy sovereignty AI翻译
  作者：Seibel, Shane; Luarkie, Richard; Cardenas, Daniel; Mayer, Cody; Sanchez, Ramon; Dannenberg, Matt; Panek, Bazile Minogiizhigaabo; Bond, Albert; Gordon, Zane; Morishige, Demi; Hadrick, Kourtney; Stahnke, Graham; Fofrich, Robert; Davis, Steve; Tallman, Richard; Bowser, Brooke; Bazilian, Morgan D.
  作者单位：Colorado School of Mines; University of California System; University of California Los Angeles; Stanford University
• Spatial resolution for forest carbon maps AI翻译
  作者：Duncanson, Laura; Hunka, Neha; Jucker, Tommaso; Armston, John; Harris, Nancy; Fatoyinbo, Lola; Williams, Christopher A.; Atkins, Jeff W.; Raczka, Brett; Serbin, Shawn; Keller, Michael; Dubayah, Ralph; Babcock, Chad; Cochrane, Mark A.; Hudak, Andrew; Hurtt, George C.; Montesano, Paul M.; Moskal, L. Monika; Park, Taejin; Saatchi, Sassan; Silva, Carlos A.; Tang, Hao; Vargas, Rodrigo; Weiskittel, Aaron; Wessels, Konrad; Goetz, Scott J.
  作者单位：University System of Maryland; University of Maryland College Park; University of Bristol; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Clark University; United States Department of Agriculture (USDA); United States Forest Service; Virginia Commonwealth University; National Center Atmospheric Research (NCAR) - USA; United States Department of Agriculture (USDA); United States Forest Service; University of Minnesota System; University of Minnesota Twin Cities; University System of Maryland; University of Maryland Center for Environmental Science; United States Department of Agriculture (USDA); United States Forest Service; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Washington; University of Washington Seattle; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); State University System of Florida; University of Florida; National University of Singapore; University of Delaware; University of Maine System; University of Maine Orono; George Mason University; Northern Arizona University
• Rapid in silico directed evolution by a protein language model with EVOLVEpro AI翻译
  作者：Jiang, Kaiyi; Yan, Zhaoqing; Di Bernardo, Matteo; Sgrizzi, Samantha R.; Villiger, Lukas; Kayabolen, Alisan; Kim, B. J.; Carscadden, Josephine K.; Hiraizumi, Masahiro; Nishimasu, Hiroshi; Gootenberg, Jonathan S.; Abudayyeh, Omar O.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Whitehead Institute; Kantonsspital St. Gallen; Massachusetts Institute of Technology (MIT); University of Tokyo; University of Tokyo
  摘要：Directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima traps. Although in silico methods that use protein language models (PLMs) can provide modeled fitness landscape guidance, they struggle to generalize across diverse protein families and map to protein activity. We present EVOLVEpro, a few-shot active learning framework that combines PLMs and regression models to rapidly ...
• Tanzania's effective trophy hunting laws AI翻译
  作者：Keyyu, Julius; Fyumagwa, Robert; Mjingo, Eblate; Silayo, Dos Santos; Masenga, Emmanuel; Kakengi, Victor; Rija, Alfan; Kideghesho, Jafari
  作者单位：Sokoine University of Agriculture
• LA research facilities spared AI翻译
  作者：Brainard, Jeffrey