6732期

最新文章

• Private fusion firms put bold claims to the test AI翻译
  作者：Clery, Daniel
• Mpox drug wins approval in Japan-but it doesn't work AI翻译
  作者：Cohen, Jon
• Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin AI翻译
  作者：Carver, Alexander; Yu, Tai-Yuan; Yates, Luke A.; White, Travis; Wang, Raymond; Lister, Katie; Jasin, Maria; Zhang, Xiaodong
  作者单位：Francis Crick Institute; Imperial College London; Memorial Sloan Kettering Cancer Center
  摘要：Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central component of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1 (fidgetin-like 1), which prevents RAD51 genotoxic chromatin association in normal cells and persistent RAD51 foci upon DNA damage. The cryogenic electron microscopy-imaged structure of FIGNL1 in complex with RAD51 r...
• Citizen Scholar: Public Engagement for Social Scientists AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville
• FCHo proteins are nucleators of clathrin-mediated endocytosis (Expression of Concern of Vol 328, Pg 1281, 2010) AI翻译
  作者：Thorp, H. Holden
• US cancer institute head leaves AI翻译
  作者：[Anonymous]
• Immaculate Forms: A History of the Female Body in Four Parts AI翻译
  作者：Mulder, Tara
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• Ductilization of 2.6-GPa alloys via short-range ordered interfaces and supranano precipitates AI翻译
  作者：Yan, Yong-Qiang; Cha, Wen-Hao; Liu, Sida; Ma, Yan; Luan, Jun-Hua; Rao, Ziyuan; Liu, Chang; Shan, Zhi-Wei; Lu, Jian; Wu, Ge
  作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; RWTH Aachen University; Delft University of Technology; City University of Hong Kong; Shanghai Jiao Tong University; City University of Hong Kong
  摘要：Higher strength and higher ductility are desirable for structural materials. However, ultrastrong alloys inevitably show decreased strain-hardening capacity, limiting their uniform elongation. We present a supranano (<10 nanometers) and short-range ordering design for grain interiors and grain boundary regions, respectively, in fine-grained alloys based on vanadium, cobalt, and nickel, with additions of tungsten, copper, aluminum, and boron. The pronounced grain boundary-related strengthening ...
• Citizen of science AI翻译
  作者：Leshner, Alan I.; Thorp, H. Holden
• Highly multiplexed spatial transcriptomics in bacteria AI翻译
  作者：Sarfatis, Ari; Wang, Yuanyou; Twumasi-Ankrah, Nana; Moffitt, Jeffrey R.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hindered by the massive density of bacterial messenger RNA. To overcome this challenge, we combined 1000-fold volumetric expansion with multiplexed error-robust fluorescence in situ hybridization (MERFISH) to create bacterial-MERFISH. This method enables high-throughput, spatially resolved profiling ...