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作者：Batra, Sahil; Allwein, Benjamin; Kumar, Charanya; Devbhandari, Sujan; Bruening, Jan-Gert; Bahng, Soon; Lee, Chong M.; Marians, Kenneth J.; Hite, Richard K.; Remus, Dirk
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
摘要：DNA G-quadruplexes (G4s) are non-B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA using reconstituted yeast and human replisomes. We demonstrate that a single G4 in the leading strand template is sufficient to stall replisomes by arresting the CMG helicase. Cryo-electron microscopy structures of stalled yeast and human CMG compl...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Kistler, Logan; Freitas, Fabio de Oliveira; Gutaker, Rafal M.; Maezumi, S. Yoshi; Ramos-Madrigal, Jazmin; Simon, Marcelo F.; Mendoza F, J. Moises; Drovetski, Sergei V.; Loiselle, Hope; de Oliveira, Eder Jorge; Vieira, Eduardo Alano; Carvalho, Luiz Joaquim Castelo Branco; Perez, Marina Ellis; Lin, Audrey T.; Liu, Hsiao-Lei; Miller, Rachel; Przelomska, Natalia A. S.; Ratan, Aakrosh; Wales, Nathan; Wann, Kevin; Zhang, Shuya; Garcia, Magdalena; Valenzuela, Daniela; Rothhammer, Francisco; Santoro, Calogero M.; Domic, Alejandra I.; Capriles, Jose M.; Allaby, Robin G.
作者单位：Smithsonian Institution; Smithsonian National Museum of Natural History; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Genetic Resources & Biotechnology; Royal Botanic Gardens, Kew; Max Planck Society; University of Copenhagen; Smithsonian Institution; Smithsonian National Museum of Natural History; University of Washington; University of Washington Seattle; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Mandioca & Fruticultura; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Cerrados; University of Warwick; American Museum of Natural History (AMNH); McMaster University; University of Portsmouth; University of Virginia; University of York - UK; Texas A&M University System; Texas A&M University College Station; Universidad de Tarapaca; Universidad de Tarapaca; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Manioc-also called cassava and yuca-is among the world's most important crops, originating in South America in the early Holocene. Domestication for its starchy roots involved a near-total shift from sexual to clonal propagation, and almost all manioc worldwide is now grown from stem cuttings. In this work, we analyze 573 new and published genomes, focusing on traditional varieties from the Americas and wild relatives from herbaria, to reveal the effects of this shift to clonality. We observe ...
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作者：Inouye, Brian D.
作者单位：State University System of Florida; Florida State University; Stockholm University
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作者：Wei, Xiaoqin; Qian, Wei; Narasimhan, Harish; Chan, Ting; Liu, Xue; Arish, Mohd; Young, Samuel; Li, Chaofan; Cheon, In Su; Yu, Qing; Almeida-Santos, Gislane; Zhao, Xiao-Yu; Yeatts, Eric V.; Spear, Olivia J.; Yi, Megan; Parimon, Tanyalak; Fang, Yinshan; Hahn, Young S.; Bullock, Timothy N. J.; Somerville, Lindsay A.; Kaplan, Mark H.; Sperling, Anne I.; Shim, Yun Michael; Vassallo, Robert; Chen, Peter; Ewald, Sarah E.; Roden, Anja C.; Que, Jianwen; Jiang, Dianhua; Sun, Jie
作者单位：University of Virginia; University of Virginia; University of Virginia; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Columbia University; University of Virginia; University of Virginia; Indiana University System; Indiana University Indianapolis; Mayo Clinic; Mayo Clinic
摘要：Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral infections. Peroxisomes were found to modulate lipid metabolism and mitochondrial health in a macrophage type-specific manner and enhanced alveolar macrophage-mediated tissue repair and alveolar regeneration after viral infection. Peroxisomes also ...
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作者：Brainard, Jeffrey
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作者：Clery, Daniel
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作者：Currano, Ellen D.
作者单位：University of Wyoming; University of Wyoming
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作者：Kilgore, Henry R.; Chinn, Itamar; Mikhael, Peter G.; Mitnikov, Ilan; Van Dongen, Catherine; Zylberberg, Guy; Afeyan, Lena; Banani, Salman F.; Wilson-Hawken, Susana; Lee, Tong Ihn; Barzilay, Regina; Young, Richard A.
作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Massachusetts Institute of Technology (MIT)
摘要：Cells have evolved mechanisms to distribute similar to 10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. We developed a protein language model, ProtGPS, that predicts with high performance the compartment localization of human proteins excluded from the training set. ProtGPS succe...
