6739期

最新文章

• Studies seek signs of consciousness before birth AI翻译
  作者：Servick, Kelly
• Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms AI翻译
  作者：Xia, Xian; Shimogawa, Michelle M.; Wang, Hui; Liu, Samuel; Wijono, Angeline; Langousis, Gerasimos; Kassem, Ahmad M.; Wohlschlegel, James A.; Hill, Kent L.; Zhou, Z. Hong
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：The flagellum of Trypanosoma brucei drives the parasite's characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-resolution (up to 2.8 angstrom) cryo-electron microscopy structures of T. brucei flagellar doublet microtubules (DMTs). Integrated modeling identified 154 different axonemal proteins inside and outside the DMT and, together with genetic and proteomic i...
• Large AI models are cultural and social technologies AI翻译
  作者：Farrell, Henry; Gopnik, Alison; Shalizi, Cosma; Evans, James
  作者单位：Johns Hopkins University; Johns Hopkins University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; The Santa Fe Institute; Carnegie Mellon University; Carnegie Mellon University; University of Chicago
• Tunneling nanotube-like structures regulate distant cellular interactions during heart formation AI翻译
  作者：Miao, Lianjie; Lu, Yangyang; Nusrat, Anika; Fan, Guizhen; Zhang, Shaohua; Zhao, Luqi; Wu, Chia-Ling; Guo, Hongyan; Huyen, Trang Le Nu; Zheng, Yi; Fan, Zhen-Chuan; Shou, Weinian; Schwartz, Robert J.; Liu, Yu; Kumar, Ashok; Sui, Haixin; Serysheva, Irina I.; Burns, Alan R.; Wan, Leo Q.; Zhou, Bin; Evans, Sylvia M.; Wu, Mingfu
  作者单位：University of Houston System; University of Houston; University of Texas System; University of Texas Health Science Center Houston; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Center for Excellence in Molecular Cell Science, CAS; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Zhejiang University; Zhejiang University; Indiana University System; Indiana University Bloomington; University of Houston System; University of Houston; Wadsworth Center; State University of New York (SUNY) System; State University of New York (SUNY) System; University at Albany, SUNY; University of Houston System; University of Houston; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; University of California System; University of California San Diego
  摘要：In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and en...
• No sign that vaccine advisers are beholden to industry AI翻译
  作者：Wadman, Meredith
• Identification of antigen-presenting cell-T cell interactions driving immune responses to food AI翻译
  作者：Canesso, Maria Cecilia Campos; de Castro, Tiago Bruno Rezende; Nakandakari-Higa, Sandra; Lockhart, Ainsley; Luehr, Julia; Bortolatto, Juliana; Parsa, Roham; Esterhazy, Daria; Lyu, Mengze; Liu, Tian-Tian; Murphy, Kenneth M.; Sonnenberg, Gregory F.; Reis, Bernardo S.; Victora, Gabriel D.; Mucida, Daniel
  作者单位：Rockefeller University; Rockefeller University; University of Chicago; Cornell University; Weill Cornell Medicine; Washington University (WUSTL); Howard Hughes Medical Institute; Rockefeller University
  摘要：The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4+ T cells and inducing their differentiation into regulatory (peripheral regulatory T cell) or inflammatory [T helper (Th) cell] subsets. We used a proximity labeling method (LIPSTIC) to identify APCs that presented dietary antigens under tolerizing and inflammatory conditions and to u...
• Face to face with the first known Western European AI翻译
  作者：Gibbons, Ann
• How does Antarctic ice deform? AI翻译
  作者：Riel, Bryan
  作者单位：Zhejiang University
  摘要：A deep-learning model infers large-scale dynamics of Antarctic ice shelves
• Evolutionary adaptations of doublet microtubules in trypanosomatid parasites AI翻译
  作者：Doran, Matthew H.; Niu, Qingwei; Zeng, Jianwei; Beneke, Tom; Smith, James; Ren, Peter; Fochler, Sophia; Coscia, Adrian; Hoeoeg, Johanna L.; Meleppattu, Shimi; Lishko, Polina V.; Wheeler, Richard J.; Gluenz, Eva; Zhang, Rui; Brown, Alan
  作者单位：Harvard University; Harvard Medical School; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Oxford; University of Bern; University of Gothenburg; University of Oxford; University of Edinburgh; University of Wurzburg; Harry Perkins Institute of Medical Research
  摘要：The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet microtubules (DMTs). In this work, we present cryo-electron microscopy structures of DMTs from two trypanosomatid species, Leishmania tarentolae and Crithidia fasciculata, at resolutions up to 2.7 angstrom. The structures revealed 27 trypanosomatid-specific microtubule inner proteins, a specialized dyn...
• Reading palms to characterize islands: Rattan palms illuminate the drivers of biodiversity in tropical Asia AI翻译
  作者：Holmquist, Anna J.; Gillespie, Rosemary G.
  作者单位：University of California System; University of California Berkeley