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作者：Wai, Jonathan
作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
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作者：Xia, Yuanxing
作者单位：Hohai University
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作者：Abdallatif, Yousef
作者单位：Necmettin Erbakan University
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作者：Elshrief, Malk
作者单位：Egyptian Knowledge Bank (EKB); Tanta University
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作者：Mervis, Jeffrey
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作者：Martin-Rufino, Jorge Diego; Caulier, Alexis; Lee, Seayoung; Castano, Nicole; King, Emily; Joubran, Samantha; Jones, Marcus; Goldman, Seth R.; Arora, Uma P.; Wahlster, Lara; Lander, Eric S.; Sankaran, Vijay G.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University
摘要：Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb-multiome, to simultaneously profile chromatin accessibility and gene expression in single cells with CRISPR-mediated perturbation of master transcription factors (TFs). We examined the connection between TFs, accessible regions, and gene expression across the genome throughout hematopoietic diffe...
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作者：Kalan, Ammie K.; Luncz, Lydia V.
作者单位：University of Victoria; Max Planck Society
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作者：Shakir, Sara
作者单位：Universite de Bordeaux; INRAE
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作者：Pillai, Eva K.; Brunet, Thibaut
作者单位：European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
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作者：Yang, Yuanheng; Hao, Cong; Jiao, Tingying; Yang, Zidan; Li, Hui; Zhang, Yuqing; Zhang, Weiya; Doherty, Michael; Sun, Chuying; Yang, Tuo; Li, Jiatian; Wu, Jing; Zhang, Mengjiao; Wang, Yilun; Xie, Dongxing; Wang, Tingjian; Wang, Ning; Huang, Xi; Li, Changjun; Gonzalez, Frank J.; Wei, Jie; Xie, Cen; Zeng, Chao; Lei, Guanghua
作者单位：Central South University; Central South University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Fudan University; Central South University; Central South University; Central South University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; University of Nottingham; Nanjing University of Chinese Medicine; Central South University; Central South University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Central South University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Central South University; Furong Laboratory; Central South University
摘要：Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid X receptor (FXR)-the receptor of GUDCA-alleviated osteoarthritis through intestine-secreted glucagon-like peptide 1 (GLP-1) in mice. GLP-1 receptor blockade attenuated these effects, whereas GLP-1 receptor activation mitigated osteoarthritis. Osteoarthritis ...
