作者：Ferris, Elliott; Gonzalez Murcia, Josue D.; Rodriguez, Adriana Cristina; Steinwand, Susan; Stacher Horndli, Cornelia; Traenkner, Dimitri; Maldonado-Catala, Pablo J.; Gregg, Christopher
作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Extreme metabolic adaptations can elucidate genetic programs that govern mammalian metabolism. Here, we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory elements (CREs) and metabolic programs. We characterized mouse hypothalamus gene expression and chromatin dynamics across fed, fasted, and refed states and then used comparative genomics of hibernating versus nonhibernating lineages to identify cis elements with convergent changes in hibernators. ...
作者：Villanueva, D.; Stengel, M.; Hoose, C.; Bruno, O.; Jeggle, K.; Ansmann, A.; Lohmann, U.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Deutscher Wetterdienst; Helmholtz Association; Karlsruhe Institute of Technology; Leibniz Association; Leibniz Institut fur Tropospharenforschung (TROPOS)
摘要：Clouds between -39 degrees and 0 degrees C can be topped by a liquid or ice layer, which affects their radiative forcing and precipitation. The cloud-top ice-to-total frequency (ITF) quantifies the occurrence of clouds with an ice top relative to total cloud occurrence, but the factors controlling ITF are poorly understood. Using 35 years of satellite data, we show that in the Northern Hemisphere, between -15 degrees and -30 degrees C, dust aerosol is strongly correlated with ITF in both time ...
作者：Wachsmuth, Tommy; Kluifhooft, Robert; Mueller, Mira; Zeiss, Leon; Kathan, Michael
作者单位：Humboldt University of Berlin
摘要：Precise mechanical manipulation of molecules is inherently difficult owing to random thermal motion. Although directed movement on the molecular scale has been achieved, using it to impose specific-especially energetically disfavored-shapes on molecules and construct mechanically interlocked structures remains a fundamental challenge. In this study, we report the synthesis of a catenane enabled by a molecular motor that winds molecular strands into discrete entangled structures, each defined b...
作者：Caniels, Tom G.; Prabhakaran, Madhu; Ozorowski, Gabriel; MacPhee, Kellie J.; Wu, Weiwei; van der Straten, Karlijn; Agrawal, Sashank; Derking, Ronald; Reiss, Emma I. M. M.; Millard, Katrina; Turroja, Martina; Desrosiers, Aimee; Bethony, Jeffrey; Malkin, Elissa; Liesdek, Marinus H.; van der Veen, Annelou; Klouwens, Michelle; Snitselaar, Jonne L.; Bouhuijs, Joey H.; Bronson, Rhianna; Jean-Baptiste, Jalen; Gajjala, Suprabhath; Rikhtegaran Tehrani, Zahra; Benner, Alison; Ramaswami, Mukundhan; Duff, Michael O.; Liu, Yung-Wen; Sato, Alicia H.; Kim, Ju Yeong; Baken, Isabel J. L.; Mendes Silva, Catarina; Bijl, Tom P. L.; van Rijswijk, Jacqueline; Burger, Judith A.; Cupo, Albert; Yasmeen, Anila; Phulera, Swastik; Lee, Wen-Hsin; Randall Jr, Kipchoge N.; Zhang, Shiyu; Corcoran, Martin M.; Regadas, Isabel; Sullivan, Alex C.; Brown, David M.; Bohl, Jennifer A.; Greene, Kelli M.; Gao, Hongmei; Yates, Nicole L.; Sawant, Sheetal; Prins, Jan M.; Kootstra, Neeltje A.; Kaminsky, Stephen M.; Barin, Burc; Rahaman, Farhad; Meller, Margaret; Philiponis, Vince; Laufer, Dagna S.; Lombardo, Angela; Mwoga, Lindsey; Shotorbani, Solmaz; Holman, Drienna; Koup, Richard A.; Klasse, Per Johan; Karlsson Hedestam, Gunilla B.; Tomaras, Georgia D.; van Gils, Marit J.; Montefiori, David C.; Mcdermott, Adrian B.; Hyrien, Ollivier; Moore, John P.; Wilson, Ian A.; Ward, Andrew B.; Diemert, David J.; de Bree, Godelieve J.; Andrews, Sarah F.; Caskey, Marina; Sanders, Rogier W.
作者单位：University of Amsterdam; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Scripps Research Institute; Fred Hutchinson Cancer Center; Rockefeller University; George Washington University; University of Amsterdam; Cornell University; Weill Cornell Medicine; Karolinska Institutet; National Institutes of Health (NIH) - USA; Duke University; University of Amsterdam; Cornell University; Weill Cornell Medicine; International AIDS Vaccine Initiative; Scripps Research Institute
摘要：A protective HIV vaccine will need to induce broadly neutralizing antibodies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging. In a double-blinded, placebo-controlled phase 1 human clinical trial, the recombinant, germline-targeting envelope glycoprotein (Env) trimer BG505 SOSIP.v4.1-GT1.1, adjuvanted with AS01B, induced bnAb precursors of the VRC01-class at a high frequency in the majority of vaccine recipients. These bnAb precursors, which target the CD4 recept...
作者：Ferrante, Lucas; Vilani, Rodrigo Machado; Apurina, Waldemiro; Gabriel Mura, Filipe; Satyro, Natalia; Elias de Oliveira, Vanessa; Lui, Lizandro; Losekann, Cristiana; Grin, Eduardo; Luiz Marenco dos Santos, Andre
作者单位：Universidade de Sao Paulo; Universidade Federal de Amazonas; Universidade Federal do Estado do Rio de Janeiro; Universidade Federal de Minas Gerais; Universidade Federal do ABC (UFABC); Universidade Federal do Espirito Santo; Getulio Vargas Foundation; Universidade Federal do Rio Grande do Sul
