作者：Goto, Norihiro; Westcott, Peter M. K.; Goto, Saori; Imada, Shinya; Taylor, Martin S.; Eng, George; Braverman, Jonathan; Deshpande, Vikram; Jacks, Tyler; Agudo, Judith; Yilmaz, Omer H.
作者单位：Massachusetts Institute of Technology (MIT); Cold Spring Harbor Laboratory; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of California System; University of California Berkeley; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; The New York Stem Cell Foundation; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：A hallmark of cancer is the avoidance of immune destruction. This process has been primarily investigated in locally advanced or metastatic cancer1-3; however, much less is known about how pre-malignant or early invasive tumours evade immune detection. Here, to understand this process in early colorectal cancers (CRCs), we investigated how naive colon cancer organoids that were engineered in vitro to harbour Apc-null, KrasG12D and Trp53-null (AKP) mutations adapted to the in vivo native coloni...
作者：Shao, Qiming
作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
摘要：Complex magnetic structures called skyrmions have been generated on a nanometre scale and controlled electrically - a promising step for fast, energy-efficient computer hardware systems that can store large amounts of data.
作者：Takai, Hiroyuki; Aria, Valentina; Borges, Pamela; Yeeles, Joseph T. P.; de Lange, Titia
作者单位：Rockefeller University; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC Laboratory Molecular Biology
摘要：Telomerase adds G-rich telomeric repeats to the 3 ' ends of telomeres1, counteracting telomere shortening caused by loss of telomeric 3 ' overhangs during leading-strand DNA synthesis ('the end-replication problem'2). Here we report a second end-replication problem that originates from the incomplete duplication of the C-rich telomeric repeat strand (C-strand) by lagging-strand DNA synthesis. This problem is resolved by fill-in synthesis mediated by polymerase alpha-primase bound to Ctc1-Stn1-...
作者：[Anonymous]
摘要：New leadership is giving the academy a stronger voice for the continent's scientists, following one of its most testing periods.
作者：Bolhuis, Johan J.; Crain, Stephen; Fong, Sandiway; Moro, Andrea
作者单位：University of Cambridge; Macquarie University; University of Arizona; IUSS PAVIA
摘要：Letter to the Editor
