-
作者：Kudelin, Igor; Groman, William; Ji, Qing-Xin; Guo, Joel; Kelleher, Megan L.; Lee, Dahyeon; Nakamura, Takuma; Mclemore, Charles A.; Shirmohammadi, Pedram; Hanifi, Samin; Cheng, Haotian; Jin, Naijun; Wu, Lue; Halladay, Samuel; Luo, Yizhi; Dai, Zhaowei; Jin, Warren; Bai, Junwu; Liu, Yifan; Zhang, Wei; Xiang, Chao; Chang, Lin; Iltchenko, Vladimir; Miller, Owen; Matsko, Andrey; Bowers, Steven M.; Rakich, Peter T.; Campbell, Joe C.; Bowers, John E.; Vahala, Kerry J.; Quinlan, Franklyn; Diddams, Scott A.
作者单位：National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; California Institute of Technology; University of California System; University of California Santa Barbara; University of Virginia; Yale University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of Colorado System; University of Colorado Boulder
摘要：Numerous modern technologies are reliant on the low-phase noise and exquisite timing stability of microwave signals. Substantial progress has been made in the field of microwave photonics, whereby low-noise microwave signals are generated by the down-conversion of ultrastable optical references using a frequency comb1-3. Such systems, however, are constructed with bulk or fibre optics and are difficult to further reduce in size and power consumption. In this work we address this challenge by l...
-
作者：Forrester, Nikki; Castro, Gabriel Renato
摘要：Marine biologist Gabriel Renato Castro cultivates compounds from cyanobacteria to support agriculture and the environment.
-
作者：Xie, Xiao; Moon, Patrick J.; Crossley, Steven W. M.; Bischoff, Amanda J.; He, Dan; Li, Gen; Dao, Nam; Gonzalez-Valero, Angel; Reeves, Audrey G.; McKenna, Jeffrey M.; Elledge, Susanna K.; Wells, James A.; Toste, F. Dean; Chang, Christopher J.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Novartis; Novartis USA; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Methods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics(1, 2-3). Owing to their high nucleophilicity, cysteine and lysine residues are the most common points of attachment for protein bioconjugation chemistry through acid-base reactivity(3,4). Here we report a redox-based strategy for bioconjugation of tryptophan, the rarest amino acid, using oxaziridine reagents that mim...
-
作者：Ong, Sandy
摘要：The country is keen to boost its production of medical technology to reduce its reliance on imports. Analysts discuss the impact of policies.
-
作者：Schmidt, Gavin
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Goddard Institute for Space Studies
摘要：Taking into account all known factors, the planet warmed 0.2 degrees C more last year than climate scientists expected. More and better data are urgently needed.
-
作者：Bridges, Alice D.; Royka, Amanda; Wilson, Tara; Lockwood, Charlotte; Richter, Jasmin; Juusola, Mikko; Chittka, Lars
作者单位：University of London; Queen Mary University London; University of Sheffield; University of Sheffield; Yale University
摘要：Culture refers to behaviours that are socially learned and persist within a population over time. Increasing evidence suggests that animal culture can, like human culture, be cumulative: characterized by sequential innovations that build on previous ones1. However, human cumulative culture involves behaviours so complex that they lie beyond the capacity of any individual to independently discover during their lifetime1-3. To our knowledge, no study has so far demonstrated this phenomenon in an...
-
作者：Lukauskas, Saulius; Tvardovskiy, Andrey; Nguyen, Nhuong V.; Stadler, Mara; Faull, Peter; Ravnsborg, Tina; Aygenli, Bihter Ozdemir; Dornauer, Scarlett; Flynn, Helen; Lindeboom, Rik G. H.; Barth, Teresa K.; Brockers, Kevin; Hauck, Stefanie M.; Vermeulen, Michiel; Snijders, Ambrosius P.; Mueller, Christian L.; DiMaggio, Peter A.; Jensen, Ole N.; Schneider, Robert; Bartke, Till
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Imperial College London; Imperial College London; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Francis Crick Institute; University of Southern Denmark; University of Southern Denmark; Radboud University Nijmegen; Netherlands Cancer Institute; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Simons Foundation; Flatiron Institute; University of Munich; German Center for Diabetes Research (DZD); Northwestern University; University of Munich
摘要：DNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome1,2. While many 'readers' of individual modifications have been described3-5, how chromatin states comprising composite modification signatures, histone variants and internucleosomal linker DNA are interpreted is a major open question. Here we use a multidimensional proteomics strategy to systematically examine the interaction of around 2,000 nuclear proteins with over 80 modified ...
-
作者：Thornton, Alex
作者单位：University of Exeter
摘要：It has been argued that human culture rests on a unique ability to learn from others more than we could possibly learn alone in a lifetime. Two studies show that we share this ability with bumblebees and chimpanzees.
-
作者：Nowogrodzki, Julian
摘要：A Dune-loving worm palaeontologist makes the case that worms have been just as important on Earth as they are in the blockbuster film.
-
作者：Crane, Yelena
摘要：Passing time.
