6762期

最新文章

• A protein tunnel helps stressed lysosomes swell AI翻译
  作者：Lippincott-Schwartz, Jennifer
  作者单位：Howard Hughes Medical Institute
• Disability and AI: Much more than assistive technologies AI翻译
  作者：Scully, Jackie Leach
  作者单位：University of New South Wales Sydney; University of New South Wales Sydney
• Don't blame the algorithms for online polarization AI翻译
  作者：Richter, Hannah
• Increasing global human exposure to wildland fires despite declining burned area AI翻译
  作者：Teymoor Seydi, Seyd; Abatzoglou, John T.; Jones, Matthew W.; Kolden, Crystal A.; Filippelli, Gabriel; Hurteau, Matthew D.; AghaKouchak, Amir; Luce, Charles H.; Miao, Chiyuan; Sadegh, Mojtaba
  作者单位：Boise State University; University of California System; University of California Merced; University of East Anglia; Indiana University System; Indiana University Indianapolis; University of New Mexico; University of California System; University of California Irvine; University of California System; University of California Irvine; United States Department of Agriculture (USDA); United States Forest Service; Beijing Normal University
  摘要：Although half of Earth's population resides in the wildland-urban interface, human exposure to wildland fires remains unquantified. We show that the population directly exposed to wildland fires increased 40% globally from 2002 to 2021 despite a 26% decline in burned area. Increased exposure was mainly driven by enhanced colocation of wildland fires and human settlements, doubling the exposure per unit burned area. We show that population dynamics accounted for 25% of the 440 million human exp...
• Load and lock: An emerging class of therapeutics that influence macromolecular dissociation AI翻译
  作者：Deshaies, Raymond J.; Potts, Patrick Ryan
  摘要：Biology is governed by macromolecular interactions, perturbation of which often lies at the heart of disease. Most therapeutic drugs, whether they are small molecules or biologics, exert their effects through impeding such interactions, whether they are of an enzyme with its substrate or a ligand with its receptor. Conversely, a handful of approved drugs and a larger number of candidates in development have the opposite effect: They either activate or inhibit a biological output by stabilizing...
• Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety AI翻译
  作者：Wood, Christian M.; Tizkar, Rana Banai; Fort, Martina; Zhang, Xinhu; Mulvihill, Kevin G.; Liao, Naixuan; Cockcroft, Gemma J.; McIver, Lauren B.; Sawiak, Stephen J.; Roberts, Angela C.
  作者单位：University of Cambridge; University of Cambridge; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille
  摘要：The dorsolateral prefrontal cortex (dlPFC) is a higher-order brain structure targeted for noninvasive stimulation for treatment-resistant depression. Nonetheless, its causal role in emotion regulation is unknown. We discovered that inactivating dlPFC area 46 in marmosets blunts appetitive motivation and heightens threat reactivity. The effects were asymmetric-dependent on the left hemisphere only-and were mediated through projections to pregenual cingulate area 32. The antidepressant ketamine ...
• LYVAC/PDZD8 is a lysosomal vacuolator AI翻译
  作者：Yang, Haoxiang; Xun, Jinrui; Li, Yajuan; Mondal, Awishi; Lv, Bo; Watkins, Simon C.; Shi, Lingyan; Tan, Jay Xiaojun
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California San Diego; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)-anchored lipid transfer protein PDZ domain-containing 8 (PDZD8), which we propose to be renamed as lysosomal vacuolator (LYVAC), is a general mediator of lysosomal vacuolation. Using human cell lines, we found that diverse lysosomal vacuolation inducers converged on lysosomal osmotic stress, triggerin...
• Outshining molecular disorder with light AI翻译
  作者：Son, Minjung
  作者单位：Boston University
• Electrical coherent driving of chiral antiferromagnet AI翻译
  作者：Takeuchi, Yutaro; Sato, Yuma; Yamane, Yuta; Yoon, Ju-Young; Kanno, Yukinori; Uchimura, Tomohiro; De Zoysa, K. Vihanga; Han, Jiahao; Kanai, Shun; Ieda, Jun'ichi; Ohno, Hideo; Fukami, Shunsuke
  作者单位：Tohoku University; National Institute for Materials Science; National Institute for Materials Science; Tohoku University; Tohoku University; Tohoku University; Tohoku University; Tohoku University; National Institutes for Quantum Science & Technology; Japan Atomic Energy Agency; Tohoku University
  摘要：Electric current driving of antiferromagnetic states at radio or higher frequencies remains challenging to achieve. In this study, we report all-electrical, gigahertz-range coherent driving of chiral antiferromagnet manganese-tin (Mn3Sn) nanodot samples. High coherence in multiple trials and threshold current insensitive to pulse width, in contrast to results observed with ferromagnets, were achieved in subnanosecond range, allowing 1000/1000 switching by 0.1-nanosecond pulses at zero field. T...
• A shared circuit might link depression and anxiety AI翻译
  作者：Treadway, Michael T.
  作者单位：Emory University; Emory University