8005期

最新文章

• The hagfish genome and the evolution of vertebrates AI翻译
  作者：Marletaz, Ferdinand; Timoshevskaya, Nataliya; Timoshevskiy, Vladimir A.; Parey, Elise; Simakov, Oleg; Gavriouchkina, Daria; Suzuki, Masakazu; Kubokawa, Kaoru; Brenner, Sydney; Smith, Jeramiah J.; Rokhsar, Daniel S.
  作者单位：University of London; University College London; Okinawa Institute of Science & Technology Graduate University; University of Kentucky; University of Vienna; Shizuoka University; University of Tokyo; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI); University of London; University College London
  摘要：As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial window into early vertebrate evolution1-3. Here we investigate the complex history, timing and functional role of genome-wide duplications4-7 and programmed DNA elimination8,9 in vertebrates in the light of a chromosome-scale genome sequence for the brown hagfish Eptatretus atami. Combining evidence from syntenic and phylogenetic analyses, we establish a comprehensive picture of vertebrate genome evoluti...
• Five million years of Antarctic Circumpolar Current strength variability AI翻译
  作者：Lamy, Frank; Winckler, Gisela; Arz, Helge W.; Farmer, Jesse R.; Gottschalk, Julia; Lembke-Jene, Lester; Middleton, Jennifer L.; van der Does, Michelle; Tiedemann, Ralf; Alvarez Zarikian, Carlos; Basak, Chandranath; Brombacher, Anieke; Dumm, Levin; Esper, Oliver M.; Herbert, Lisa C.; Iwasaki, Shinya; Kreps, Gaston; Lawson, Vera J.; Lo, Li; Malinverno, Elisa; Martinez-Garcia, Alfredo; Michel, Elisabeth; Moretti, Simone; Moy, Christopher M.; Ravelo, Ana Christina; Riesselman, Christina R.; Saavedra-Pellitero, Mariem; Sadatzki, Henrik; Seo, Inah; Singh, Raj K.; Smith, Rebecca A.; Souza, Alexandre L.; Stoner, Joseph S.; Toyos, Maria; de Oliveira, Igor M. Venancio P.; Wan, Sui; Wu, Shuzhuang; Zhao, Xiangyu
  作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Bremen; Columbia University; Columbia University; Leibniz Institut fur Ostseeforschung Warnemunde; University of Massachusetts System; University of Massachusetts Boston; University of Kiel; Texas A&M University System; Texas A&M University College Station; University of Delaware; Yale University; State University of New York (SUNY) System; Stony Brook University; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Rutgers University System; Rutgers University New Brunswick; National Taiwan University; University of Milano-Bicocca; Max Planck Society; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; University of Otago; University of California System; University of California Santa Cruz; University of Portsmouth; Korea Institute of Ocean Science & Technology (KIOST); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bhubaneswar; University of Massachusetts System; University of Massachusetts Amherst; Universidade Federal do Rio de Janeiro; Oregon State University; Universidade Federal Fluminense; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; University of Lausanne; Research Organization of Information & Systems (ROIS); National Institute of Polar Research (NIPR) - Japan
  摘要：The Antarctic Circumpolar Current (ACC) represents the world's largest ocean-current system and affects global ocean circulation, climate and Antarctic ice-sheet stability 1-3 . Today, ACC dynamics are controlled by atmospheric forcing, oceanic density gradients and eddy activity 4 . Whereas palaeoceanographic reconstructions exhibit regional heterogeneity in ACC position and strength over Pleistocene glacial-interglacial cycles 5-8 , the long-term evolution of the ACC is poorly known. Here we...
• East-to-west human dispersal into Europe 1.4 million years ago AI翻译
  作者：Garba, R.; Usyk, V.; Yla-Mella, L.; Kamenik, J.; Stuebner, K.; Lachner, J.; Rugel, G.; Veselovsky, F.; Gerasimenko, N.; Herries, A. I. R.; Kucera, J.; Knudsen, M. F.; Jansen, J. D.
  作者单位：Czech Academy of Sciences; Nuclear Physics Institute of the Czech Academy of Sciences; Czech Academy of Sciences; National Academy of Sciences Ukraine; Institute of Archaeology, National Academy of Sciences of Ukraine; Czech Academy of Sciences; Institute of Archaeology of the Czech Academy of Sciences - Brno; Czech Academy of Sciences; Institute of Geophysics of the Czech Academy of Sciences; Charles University Prague; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Czech Geological Survey; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv; La Trobe University; University of Johannesburg; Aarhus University
  摘要：Stone tools stratified in alluvium and loess at Korolevo, western Ukraine, have been studied by several research groups1-3 since the discovery of the site in the 1970s. Although Korolevo's importance to the European Palaeolithic is widely acknowledged, age constraints on the lowermost lithic artefacts have yet to be determined conclusively. Here, using two methods of burial dating with cosmogenic nuclides4,5, we report ages of 1.42 +/- 0.10 million years and 1.42 +/- 0.28 million years for the...
• 3D-PRINTED WASTE WOOD ACTS JUST LIKE THE REAL THING AI翻译
  作者：[Anonymous]
• Powerful microscopy reveals blood-cell production in bone marrow AI翻译
  作者：Florian, M. Carolina
  作者单位：ICREA
  摘要：A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.
• Deep-sea mining plans should not be rushed AI翻译
  作者：[Anonymous]
  摘要：Why are companies and governments determined to start commercial-scale mining for rare metals, when so little is known about its wider impacts?
• Substrate-induced condensation activates plant TIR domain proteins AI翻译
  作者：Song, Wen; Liu, Li; Yu, Dongli; Bernardy, Hanna; Jirschitzka, Jan; Huang, Shijia; Jia, Aolin; Jemielniak, Wictoria; Acker, Julia; Laessle, Henriette; Wang, Junli; Shen, Qiaochu; Chen, Weijie; Li, Pilong; Parker, Jane E.; Han, Zhifu; Schulze-Lefert, Paul; Chai, Jijie
  作者单位：China Agricultural University; Max Planck Society; University of Cologne; Beijing Normal University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute; Harvard Medical School; Westlake University; Tsinghua University; Max Planck Society
  摘要：Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domains1. Effector binding enables TIR-encoded enzymatic activities that are required for TIR-NLR (TNL)-mediated immunity2,3. Many truncated TNL proteins lack effector-sensing domains but retain similar enzymatic and immune activities4,5. The mechanism underlying t...
• In retrospect 50 years after a landmark paper on bird-flight origins AI翻译
  作者：Padian, Kevin
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells (Feb, 10.1038/s41586-024-07121-9, 2024) AI翻译
  作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; McGinnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
• The structure and physical properties of a packaged bacteriophage particle AI翻译
  作者：Coshic, Kush; Maffeo, Christopher; Winogradoff, David; Aksimentiev, Aleksei
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：A string of nucleotides confined within a protein capsid contains all the instructions necessary to make a functional virus particle, a virion. Although the structure of the protein capsid is known for many virus species1,2, the three-dimensional organization of viral genomes has mostly eluded experimental probes3,4. Here we report all-atom structural models of an HK97 virion5, including its entire 39,732 base pair genome, obtained through multiresolution simulations. Mimicking the action of a...