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作者：Mallapaty, Smriti
摘要：The treatment, called NexCAR19, raises hopes that this transformative class of medicine will become more readily available in low- and middle-income countries.
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作者：Farah, Elie N.; Hu, Robert K.; Kern, Colin; Zhang, Qingquan; Lu, Ting-Yu; Ma, Qixuan; Tran, Shaina; Zhang, Bo; Carlin, Daniel; Monell, Alexander; Blair, Andrew P.; Wang, Zilu; Eschbach, Jacqueline; Li, Bin; Destici, Eugin; Ren, Bing; Evans, Sylvia M.; Chen, Shaochen; Zhu, Quan; Chi, Neil C.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Ludwig Institute for Cancer Research; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：The heart, which is the first organ to develop, is highly dependent on its form to function(1,2). However, how diverse cardiac cell types spatially coordinate to create the complex morphological structures that are crucial for heart function remains unclear. Here we integrated single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization to resolve the identity of the cardiac cell types that develop the human heart. This approach also provided a sp...
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作者：Sun, Yanjun; Nitz, Douglas A.; Xu, Xiangmin; Giocomo, Lisa M.
作者单位：Stanford University; University of California System; University of California Irvine; University of California System; University of California San Diego; University of California System; University of California Irvine
摘要：Animals in the natural world constantly encounter geometrically complex landscapes. Successful navigation requires that they understand geometric features of these landscapes, including boundaries, landmarks, corners and curved areas, all of which collectively define the geometry of the environment(1-12) .Crucial to the reconstruction of the geometric layout of natural environments are concave and convex features, such as corners and protrusions. However, the neural substrates that could under...
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作者：Russell, Thomas D.; Degenaar, Nathalie; van den Eijnden, Jakob; Maccarone, Thomas; Tetarenko, Alexandra J.; Sanchez-Fernandez, Celia; Miller-Jones, James C. A.; Kuulkers, Erik; Del Santo, Melania
作者单位：Istituto Nazionale Astrofisica (INAF); University of Amsterdam; University of Warwick; University of Oxford; Texas Tech University System; Texas Tech University; University of Lethbridge; European Space Agency; European Space Astronomy Center; Curtin University; University of Western Australia; European Space Agency; European Space Research & Technology Centre
摘要：Relativistic jets are observed from accreting and cataclysmic transients throughout the Universe, and have a profound impact on their surroundings1,2. Despite their importance, their launch mechanism is not known. For accreting neutron stars, the speed of their compact jets can reveal whether the jets are powered by magnetic fields anchored in the accretion flow3 or in the star itself4,5, but so far no such measurements exist. These objects can show bright explosions on their surface due to un...
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作者：Sultana, Farhana; McAllister, Tara; Katyaini, Suparana; Blackstock, Michael D.
作者单位：Syracuse University
摘要：Four scientists reflect on how to foster a more sustainable relationship between water and society amid complex and wide-ranging challenges.
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作者：Huddy, Timothy F.; Hsia, Yang; Kibler, Ryan D.; Xu, Jinwei; Bethel, Neville; Nagarajan, Deepesh; Redler, Rachel; Leung, Philip J. Y.; Weidle, Connor; Courbet, Alexis; Yang, Erin C.; Bera, Asim K.; Coudray, Nicolas; Calise, S. John; Davila-Hernandez, Fatima A.; Han, Hannah L.; Carr, Kenneth D.; Li, Zhe; McHugh, Ryan; Reggiano, Gabriella; Kang, Alex; Sankaran, Banumathi; Dickinson, Miles S.; Coventry, Brian; Brunette, T. J.; Liu, Yulai; Dauparas, Justas; Borst, Andrew J.; Ekiert, Damian; Kollman, Justin M.; Bhabha, Gira; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; M. S. Ramaiah University of Applied Sciences; New York University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; New York University; New York University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in comparison, has been much more complex, largely owing to the irregular shapes of protein structures(1). Here we describe extendable linear, curved and angled protein building blocks, as well as inter-block interactions, that conform to specified geome...
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作者：Conroy, Gemma
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作者：Huang, Jonathan Y.; Su, Rocky Y.; Lim, Wee Han; Feng, Mengke; van Straaten, Barnaby; Severin, Brandon; Gilbert, Will; Stuyck, Nard Dumoulin; Tanttu, Tuomo; Serrano, Santiago; Cifuentes, Jesus D.; Hansen, Ingvild; Seedhouse, Amanda E.; Vahapoglu, Ensar; Leon, Ross C. C.; Abrosimov, Nikolay V.; Pohl, Hans-Joachim; Thewalt, Michael L. W.; Hudson, Fay E.; Escott, Christopher C.; Ares, Natalia; Bartlett, Stephen D.; Morello, Andrea; Saraiva, Andre; Laucht, Arne; Dzurak, Andrew S.; Yang, Chih Hwan
作者单位：University of New South Wales Sydney; University of Oxford; Leibniz Association; Leibniz Institut fur Kristallzuchtung (IKZ); Simon Fraser University; University of Sydney
摘要：The encoding of qubits in semiconductor spin carriers has been recognized as a promising approach to a commercial quantum computer that can be lithographically produced and integrated at scale 1-10 . However, the operation of the large number of qubits required for advantageous quantum applications 11-13 will produce a thermal load exceeding the available cooling power of cryostats at millikelvin temperatures. As the scale-up accelerates, it becomes imperative to establish fault-tolerant opera...
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作者：Drew, Liam; Macdonald, Alisdair
摘要：After decades of slow progress, therapeutic vaccines that direct the immune system to attack tumours could soon become a fixture of cancer treatment.
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作者：Hiura, Satoshi
作者单位：Hokkaido University
摘要：Clever manipulation of electrons has enabled scientists to change a key property of light emitted by a device using electrically controlled magnetization. The method could lead to stable and energy-efficient information transfer.
